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COMPLICATIONS OF CHLORPROMAZINE THERAPY

Published Online:https://doi.org/10.1176/ajp.113.2.115

1. Chlorpromazine has many undesirable effects, most of which are transient and of relatively minor clinical significance.

2. Complications of greater severity occur in a significant number of cases but generally resolve rapidly and without residuals.

3. Four categories of complications are distinguishable: direct or indirect action on various levels of the nervous System, allergic-type reactions, responses of indefinite origin, and indirect effects of drug action.

4. Despite its numerous undesirable effects chlorpromazine is clinically a relatively safe drug.

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