EPIDEMIC ENCEPHALITIS
Abstract
Fourteen patients showing the sequels of encephalitis epidemica were treated by the intravenous injection of neutral acriflavine. There was marked improvement in three instances; improvement in seven and slight improvement or none in four. The series is too small and the time which has elapsed since the injections too brief to permit even these moderate conclusions to stand as final. Unfortunately, it was necessary to take the clinical material which offered at the time. Our choice was practically restricted to patients with a parkinsonian syndrome which in one case—a boy of 14, was complicated by a behavior disorder, and in another—a girl of 14, by a psychoneurosis. In other words, we were dealing with well-established pathology of a type indicative of chronicity.
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There were no acute cases* available for the experiment; the period of time intervening between the initial illness and the beginning of treatment averaged about 3 years, 4 months, the shortest being 2 years. We feel that this method of treatment is promising, and it should be tested out in the acute stages of the illness and in recent sequellæ.
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