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A carbamazepine trial in chronic, treatment-refractory schizophrenia

Published Online:https://doi.org/10.1176/ajp.145.6.748

Carbamazepine was given to 12 chronic, treatment-refractory schizophrenic patients for 5 weeks. No overall change was found, but four patients significantly improved while eight worsened. Given the paucity of successful treatments for refractory schizophrenia, further study of carbamazepine appears warranted.

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