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Effects of diet on urinary excretion of MHPG in normal preadolescent boys

Published Online:https://doi.org/10.1176/ajp.140.4.476

The authors examined the effect of diets with low and high monoamine content on the 24-hour urinary excretion of 3-methoxy-4- hydroxyphenylglycol (MHPG) and creatinine in eight healthy preadolescent boys. The subjects were admitted to a clinical research center and were placed on a diet low in monoamines--the vanillylmandelic acid (VMA)-exclusion diet--for 5 consecutive days. They were switched on the 6th day to a diet rich in monoamines, and urine specimens were collected for 4 more consecutive days. There were no differences in MHPG or creatinine excretion between the urine taken on the low and high monoamine diet days.

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