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Tricyclic antidepressant sample stability and the vacutainer effect

Published Online:https://doi.org/10.1176/ajp.138.9.1247

The authors studied the effects of different sample handling techniques on 17 tricyclic plasma samples. They found that the samples were stable at room temperature for up to 3 days when kept in a glass tube sealed with Parafilm, but the samples were not stable when stored in a Vacutainer tube with the stopper in contact with the plasma.

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