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Published Online:https://doi.org/10.1176/ajp.127.9.1128

Data from families of 100 intensively studied patients with depressive disease (unipolar affective disorder) and a review of the literature suggest that genetic factors play a role in the etiology of depressive disease. It is also possible that this disease may in fact be a heterogeneous group of illnesses with different manifestations, for example, in males and females. The authors stress the need for further studies to test their hypothesis.

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