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Published Online:https://doi.org/10.1176/ajp.124.12.1653

The authors describe six persons who were raised as members of their assigned sex but who felt that they belonged to the opposite sex. At puberty all developed some sort of cross-sex change, in effect confirming their earliest gender wishes. A possible explanation is that a biological force—a hidden hormonal or CNS aberration—exerted an effect upon gender identity development.

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