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Published Online:https://doi.org/10.1176/ajp.122.10.1185

A clinical trial of alpha-methyldopa (Aldomet) in elated states is reported. Four drug trials were conducted in three "manic" patients at dosage levels up to 6 gms. per day. No therapeutic effect was noted, although a pharmacologic effect as evidenced by a fall in blood pressure in three of four trials was noted. However, further studies with this compound in psychiatric patients are indicated before final conclusions can be drawn.

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