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Published Online:https://doi.org/10.1176/ajp.119.11.1098

A patient is reported who showed similar attacks of mania separated by an interval of 30 years associated on each occasion with the use of a drug which causes marked C.N.S. stimulation. It would seem, for this patient, at least, that the profound disturbance of C. N. S. function sometimes associated with these drugs served as an additional severe stress causing personality disruption and a manic illness. Since many compounds of this kind are being used increasingly for the treatment of mental

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