RECURRENT THIOPERAZINE-INDUCED EXTRAPYRAMIDAL REACTION FOLLOWING PLACEBO SUBSTITUTION FOR MAINTENANCE ANTIPARKINSON DRUG
Abstract
A placebo was abruptly substituted for maintenance antiparkinson drug in 20 patients who had previously shown evidence of a thioperazine-induced extrapyramidal reaction. Within 20 days of this controlled study extrapyramidal reactions reappeared in 16 patients (80%). The recurrence rate of phenothiazine-induced extrapyramidal reactions following withdrawal of maintenance antiparkinson drug will vary with different situations and their incidence can only be determined by clinical trial.
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