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Published Online:https://doi.org/10.1176/ajp.118.2.142

A brief survey of the literature on psychiatric symptoms in myxedema is followed by 3 case reports demonstrating that "Myxedema Madness" may present as seemingly specific organic or functional psychoses, and that psychiatric care may prove vital in the management of these patients. The successful use of EST in psychiatric symptoms resistent to thyroid substitution in myxedema is reported. The further evaluation of EST in this circumstance is suggested.

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