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Published Online:https://doi.org/10.1176/ajp.112.2.144

1. A case of Cushing's Syndrome in a 23-year old male is presented.

2. Proper diagnosis was delayed by an overwhelming psychotic picture, resembling schizophrenia.

3. Initial treatment consisting of a 2-stage roentgen irradiation of the pituitary region was rendered, producing no significant mental improvement.

4. Final treatment consisting of complete adrenalectomy, performed in 2 stages and followed by replacement therapy, resulted in complete remission of all physical and mental symptoms and signs within 6 months, following the first stage of adrenalectomy.

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