Am J Psychiatry 1992; 149:1091-1095
Copyright © 1992 by American Psychiatric Association
A monozygotic mirror-image twin pair with discordant psychiatric illnesses: a neuropsychiatric and neurodevelopmental evaluation
JB Lohr and HS Bracha
Department of Psychiatry, School of Medicine, University of California, San Diego.
One piece of genetic evidence for the biological distinctness of
schizophrenia and bipolar illness is the rarity of monozygotic twin pairs
in which one twin suffers from schizophrenia and the other from bipolar
disorder. The authors describe a pair of monozygotic mirror- image twins
with discordant diagnoses, schizophrenia in one twin and bipolar or
schizoaffective disorder in the other.
