Imipramine and social-vocational adjustment in chronic depression



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Am J Psychiatry 1988; 145:997-999
Copyright © 1988 by American Psychiatric Association

REGULAR ARTICLES

Imipramine and social-vocational adjustment in chronic depression

JH Kocsis, AJ Frances, C Voss, BJ Mason, JJ Mann and J Sweeney
Department of Psychiatry, Payne Whitney Psychiatric Clinic, New York Hospital--Cornell Medical Center 10021.

The authors compared the effects of 6 weeks of imipramine treatment with 6 weeks of placebo treatment on social and vocational impairment in chronic depression. Imipramine was associated with significantly greater pre- to posttreatment improvement of social-vocational impairments in chronic depression, suggesting that these impairments may have represented affective symptoms rather than characterologic deficits.

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