Am J Psychiatry 130:1006-1010, September 1973
doi: 10.1176/appi.ajp.130.9.1006
© 1973 American Psychiatric Association
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The Use of Lithium in Affective Disorders, III: A Double-Blind Study of Prophylaxis in Bipolar Illness
FRANK STALLONE PH.D.1,
EDWARD SHELLEY M.D.2,
JULIEN MENDLEWICZ M.D.3, , and
RONALD R. FIEVE M.D.4
1 Associate Research Scientist, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032
2 Ward Administrator, Metabolic Research Unit, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032
3 Visiting Research Fellow, Belgian American Education Foundation, Department of Medical Genetics, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Senior Psychiatrist, Brugmann Psychiatric Hospital, Brussels, Belgium; and Professor of Clinical Psychiatry, Columbia University College of Physicians and Surgeons, New York, N.Y.
4 Chief of Psychiatric Research, Department of Internal Medicine and Metabolic Research Unit, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Professor of Clinical Psychiatry, Columbia University College of Physicians and Surgeons, New York, N.Y.
The authors studied 52 manic-depressive patients who were assigned to either lithium or placebo during their normal interval phases for periods up to 28 months. Patients receiving lithium had fewer manic and depressive episodes per patient-year than placebo patients. However, this difference may have been due to a sample bias produced by a large dropout rate among patients who had manic episodes. The findings also suggest a relationship between response to lithium and family history of bipolar illness.
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