Of the 65 suspected episodes of neuroleptic malignant syndrome involving 45 patients, 22 episodes (33.8%)—involving 20 patients (44.4%)—had at least one subnormal body temperature nadir recorded within 7 days of the date that the episode reached maximal intensity. Nadirs (lowest temperatures recorded on any given day) ranged from 93.3°F to 98.2°F. Diaphoresis was observed in 11 (50%) of the episodes and more frequently in episodes with the lowest temperature nadirs, although this difference was not statistically significant (median split: 63.6% and 36.4%, respectively; Pearson’s χ2=1.64, df=1, p=0.20). Episodes with observed diaphoresis had a lower mean temperature nadir than episodes without observed diaphoresis, but once again this difference failed to reach statistical significance (95.8°F, SD=0.81; 96.7˚F, SD=1.44, respectively) (p=0.13, n.s.). These data should be treated cautiously because temperatures were taken orally, so patients’ inability to cooperate would tend to bias measurements toward lower temperatures. However, these data suggest that hypothermia may be more common in neuroleptic malignant syndrome than has been appreciated and that excessive diaphoresis may play a role. As Drs. Duggal and Nizamie imply, oscillations between hypo- and hyperthermia in neuroleptic malignant syndrome would be consistent with the model that I have proposed.