The two studies involved quite different designs, such that, taken together, they may suggest a breadth to the protective effect of religiosity in the course of depression. Whereas Dr. Koenig’s group found that religiosity hastened remission among moderately depressed patients followed for 1 year, our study found that religiosity protected against recurrence among severely depressed patients followed for 10 years. Subjects in Dr. Koenig et al.’s study were medically ill elderly patients whose depression may have been triggered by the life events of deteriorated health, decreased social functioning, and the prospect of death. Our subjects, by contrast, were mothers (mean age=41 years) of children age 6–18 years facing endemic life events, often with chronic poor social functioning. Dr. Koenig et al. emphasize that their subjects were from the Bible Belt, whereas our subjects were from a predominantly working-class area of New Haven, Conn. These differences between subjects in severity and chronicity of depression, age, clinical status, life events, and surrounding community suggest that religiosity may be broadly protective in the course of depression, buffering against the full life course of negative events in patients with varying depression histories.