Historically, the concept of human “disease” (etymologically, dis-ease) arose in response to various instances of prolonged or intense suffering and incapacity not due to an obvious wound or a deliberate attack (2). Thus, disease is not a biological or even etiological term, but rather a term of ordinary language (3), often first applied to the suffering and incapacitated person by family or friends. Only subsequent to the recognition of disease does our system of classification become relevant, insofar as it aims to identify the type of disease at hand. Applied to anxiety, a patient has psychiatric disease or disorder when his or her anxiety is such that it causes prolonged or intense suffering and incapacity—which we may define by whatever measures we care to specify. We need not invoke unverifiable evolutionary mechanisms at all (4).