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The American Journal of Psychiatry, VOL. 146, No. 4

REGULAR ARTICLES | April 01, 1989

Behavioral hyporeactivity to physostigmine in detoxified primary alcoholics

Am J Psychiatry 1989;146:538-539.

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Abstract

Changes in anergia/inhibition, mood, and pulse rate induced by intravenous physostigmine were significantly less pronounced in 26 patients with primary alcoholism than in 36 normal control subjects. These results suggest possible abnormalities in central cholinergic functioning in primary alcoholics.

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