The authors investigated the pharmacological treatment of delusional
depression by assigning patients on a random double-blind basis to
amitriptyline alone, perphenazine alone, or a combination of the two.
Fourteen (78%) of the 18 patients assigned to amitriptyline plus
perphenazine were responders, compared with seven (41%) of 17 patients
treated with amitriptyline alone and three (19%) of the 16 patients treated
with perphenazine alone. The combination of amitriptyline and perphenazine
was clearly superior (p less than .01).