The authors compared the regions of motor involvement in levodopa-
induced dyskinesia and neuroleptic-induced tardive dyskinesia.
Significantly more patients with tardive dyskinesia than parkinsonian
patients with levodopa-induced dyskinesia had lip and tongue movements.
Patients with tardive dyskinesia had significantly higher mean AIMS scores
in the orofacial region than parkinsonian patients with levodopa- induced
dyskinesia. More patients with levodopa-induced dyskinesia than those with
tardive dyskinesia demonstrated hyperkinesia in the lower extremities. Limb
and truncal movements in levodopa-induced dyskinesia were worse in patients
with more severe parkinsonism and correlated positively with the length of
Parkinson's disease. These findings suggest that these dyskinesias may
involve different pathophysiological mechanisms.