Lithium-Induced Diabetes Insipidus: Manic Symptoms, Brain and Electrolyte Correlates, and Chlorothiazide Treatment
Abstract
A patient with lithium-induced, vasopressin-insensitive diabetes insipidus was studied during two consecutive manic episodes that were successfully treated with lithium. Polyuria occurred several days after lithium-induced brain electrical changes were observed, and at serum lithium concentrations close to 1.0 mEq./liter. Polyuria began during a period of behavioral improvement and persisted after the manic symptoms subsided. Polyuria did not occur in association with serum lithium concentrations over 1.8 mEq./liter, and a fourfold increase in sodium intake did not reduce the polyuria. Chlorothiazide reduced polyuria and permitted the patient to continue the lithium treatment.
Access content
To read the fulltext, please use one of the options below to sign in or purchase access.- Personal login
- Institutional Login
- Sign in via OpenAthens
- Register for access
-
Please login/register if you wish to pair your device and check access availability.
Not a subscriber?
PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.
Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).