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Comparison of the Chromosomal Patterns Obtained from Groups of Continued Users, Former Users, and Nonusers of LSD-25
LEWIS L. JUDD; WARREN W. BRANDKAMP; WILLIAM H. MCGLOTHLIN
Am J Psychiatry 1969;126:626-635.
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Director of education, division of child psychiatry, UCLA School of Medicine, Los Angeles, Calif. 90024

Assistant research neurologist, division of neurology, UCLA School of Medicine

Lecturer and research psychologist, department of psychology, University of California at Los Angeles

1970, American Psychiatric Association

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Abstract

In a single-blind study chromosome analyses were performed on three groups of subjects: 1) nine heavy users of LSD-25 who have continued to use the drug; 2) eight heavy users of LSD-25 who have ceased to use it; and 3) eight drug-free control subjects. The results revealed no significant differences in chromosome break-age rates between any of the three groups and therefore no temporal factor was elicited regarding chromosome damage and LSD ingestion. The mean breakage rates for all three groups were 1.8 percent or less and did not support earlier findings that LSD ingestion causes an increase in chromosome aberrations over those observed in a normal control population. The authors emphasize the need for a more controlled longitudinal study.

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