Toward a Biology of Depression: Some Suggestions from Neurophysiology
Abstract
This review of recent research suggests the existence of an unstable state of central nervous system hyperexcitability in depression, and possibly in mania, with an associated but disorganized intrinsic hyperactivity. The authors propose this concept as a possible description of the prevailing neurophysiologic state of the individual with affective disorder and as complementary to other biological hypotheses currently under investigation. They conclude that the concept warrants further study, noting the need for replication and extension of many of the studies reviewed.
Access content
To read the fulltext, please use one of the options below to sign in or purchase access.- Personal login
- Institutional Login
- Sign in via OpenAthens
- Register for access
-
Please login/register if you wish to pair your device and check access availability.
Not a subscriber?
PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.
Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).
