Amphetamine salts have been prescribed for decades, primarily for treating ADHD in youth, with most safety concerns focusing on youth-specific issues, such as negative effect on normal growth that appears to be associated with these medications (1). To our knowledge, no cases of hemorrhagic stroke have been described in association with mixed amphetamine salts or other stimulants used for treatment of ADHD. However, amphetamines, cocaine, and ecstasy have all been reported to cause spontaneous intracerebral hemorrhages (3). We do not intend to suggest direct causality between the present patient's treatment with mixed amphetamine salts and hemorrhagic stroke. The intent of this report is to increase awareness among psychiatrists that, with increased prescribing of stimulants to adults with ADHD, a new level of vigilance is needed to identify safety risks salient to adults.