The Dominguez et al. report is especially timely as it relates to two areas of potential innovation in the psychoses chapter of DSM-5. I chair the Psychosis Work Group and Dr. van Os, an author of the report with Dominguez, is a member. Finding that positive psychotic symptoms are a separate pathology domain from negative/disorganized symptoms in young people with attenuated symptoms reinforces the view of schizophrenia and other psychotic disorders as syndromes rather than disease entities, and that individuals in the same class have substantial differences in psychopathology. This calls for deconstruction of the syndrome into component parts, something we advocated prior to DSM-III (2) and more recently clarified by Peralta and Cuesta (8) and in a DSM-5 lead-in conference ( 9— 12). We plan to field test the user-friendliness and reliability of a set of dimensions representing clinical phenomena such as hallucinations, delusions, disorganization, restricted affect, avolition, cognition impairment, anxiety, depression, and mania. These dimensions are supported by empirical study and may become primary targets for research and treatment development.