This statement and the findings bring up several questions. One of them is, how much are we all under the influence of the pharmaceutical industry? Who is making the greatest effort to use SSRIs, originally categorized or miscategorized as antidepressants, for anxiety disorders? Certainly the pharmaceutical industry is. Should we ignore the response of the market—i.e., in spite of all the more or less scientific evidence—that benzodiazepines are liked and considered effective, efficacious, and well tolerated by patients with anxiety disorders and their physicians? Benzodiazepines have been found to be effective in the treatment of various anxiety disorders (a review of the evidence is beyond the scope of this letter), and some of them have also been approved by the Food and Drug Administration for the treatment of panic disorder (e.g., alprazolam). During the treatment of panic disorder, many clinicians have found benzodiazepines useful in various situations, including breakthrough panic anxiety and fear of flying, and only when needed. Certainly, benzodiazepines have disadvantages, namely, the physiological dependence potential. Nevertheless, SSRIs have also several disadvantages (mentioned by Dr. Bruce et al.), and it is questionable whether they have the most favorable balance of efficacy and adverse effects for the treatment of panic disorder.