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Published Online:https://doi.org/10.1176/ajp.125.1.109

The authors studied 16 pairs of monozygotic twins—12 pairs of twins discordant for schizophrenia and four pairs of nonschizophrenic control twins—and their parents to determine the relationship between serum macroglobulin level and schizophrenia. They found no significant relation between the two factors. Evidence from these and other data suggests that serum macroglobulin levels are more influenced by factors based on sex and genetic makeup than by environment.

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