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American Journal of Psychiatry

Volume 169, Issue 9

September 2012

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In This Issue

September 2012

Page:A32
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.1699issue

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Editorials

September 2012

Lifting the Field’s “Repression” of Defenses

George Vaillant, M.D.

Pages:885–887
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050703

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September 2012

Addictive Disorders: Finding the Predisposing Traits

Alan C. Swann, M.D.

Pages:888–890
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12060779

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September 2012

Bioenergetics for Depression: Something Different for Depression

Stephen M. Strakowski, M.D.

Pages:891–893
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050720

First Page
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September 2012

Good News for Dementia Care: Caregiver Interventions Reduce Behavioral Symptoms in People With Dementia and Family Distress

Laura N. Gitlin, Ph.D.

Pages:894–897
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12060774

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Images in Psychiatry

September 2012

Nuvoluccia in her Lightdress: Lucia Joyce’s Mental Illness in Finnegans Wake

Luca Congia, Psy.D.,
Andrea Raballo, M.D., Ph.D., and
Antonio Preti, M.D.

Pages:898–899
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12030378

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Treatment in Psychiatry

September 2012

Atypical Antipsychotic Use in Patients With Dementia: Managing Safety Concerns

Martin Steinberg, M.D., and
Constantine G. Lyketsos, M.D., M.H.S.

Pages:900–906
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12030342

Abstract
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Neuropsychiatric symptoms such as agitation and delusions occur commonly in elderly patients with dementia and often cause significant distress. Data on treatment efficacy are strongest for atypical antipsychotics, but these agents must be used with great ...

Reviews and Overviews

September 2012

Fragmentation and Unpredictability of Early-Life Experience in Mental Disorders

Tallie Z. Baram, M.D., Ph.D.,
Elysia P. Davis, Ph.D.,
Andre Obenaus, Ph.D.,
Curt A. Sandman, Ph.D.,
Steven L. Small, M.D., Ph.D.,
Ana Solodkin, Ph.D., and
Hal Stern, Ph.D.

Pages:907–915
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11091347

Abstract
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Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation ...

Articles

September 2012

Change in Defense Mechanisms During Long-Term Dynamic Psychotherapy and Five-Year Outcome

J. Christopher Perry, M.P.H., M.D., and
Michael Bond, M.D.

Pages:916–925
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11091403

Abstract
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Patients treated in dynamic psychotherapy for depressive, anxious, or personality disorders were assessed over the course of their 5-year therapy for their use of defense mechanisms. Patients generally progressed from immature defenses, such as acting out,...

September 2012

Cognitive Dysfunction and Anxious-Impulsive Personality Traits Are Endophenotypes for Drug Dependence

Karen D. Ersche, Ph.D.,
Abigail J. Turton, B.Sc.,
Samuel R. Chamberlain, Ph.D.,
Ulrich Müller, M.D., Ph.D.,
Edward T. Bullmore, Ph.D., and
Trevor W. Robbins, Ph.D.

Pages:926–936
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11091421

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ObjectiveNot everyone who takes drugs becomes addicted, but the likelihood of developing drug addiction is greater in people with a family history of drug or alcohol dependence. Relatively little is known about how genetic risk mediates the development of ...

September 2012

A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder

In Kyoon Lyoo, M.D., Ph.D.,
Sujung Yoon, M.D., Ph.D.,
Tae-Suk Kim, M.D., Ph.D.,
Jaeuk Hwang, M.D., Ph.D.,
Jieun E. Kim, M.D., Ph.D.,
Wangyoun Won, M.D.,
Sujin Bae, Ph.D., and
Perry F. Renshaw, M.D., Ph.D.

Pages:937–945
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12010009

Abstract
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Antidepressants often take several weeks to work, but depressed women who took the antidepressant escitalopram plus 5 g/day of creatine monohydrate, a supplement that increases cellular energy, had earlier and greater symptom decreases than women who took ...

September 2012

Meta-Analysis of Nonpharmacological Interventions for Neuropsychiatric Symptoms of Dementia

Henry Brodaty, D.Sc., and
Caroline Arasaratnam, B.Psych.(Hons)

Pages:946–953
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11101529

Abstract
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A meta-analysis showed that 9–12 sessions of supportive help delivered in the home to family caregivers for dementia patients had a salutary effect for the patients' behavioral symptoms, such as screaming and aggression, similar in size to the effect of ...

September 2012

Effect of Alzheimer’s Disease Risk Genes on Trajectories of Cognitive Function in the Cardiovascular Health Study

Robert A. Sweet, M.D.,
Howard Seltman, M.D., Ph.D.,
James E. Emanuel, B.S.,
Oscar L. Lopez, M.D.,
James T. Becker, Ph.D.,
Joshua C. Bis, Ph.D.,
Elise A. Weamer, M.P.H.,
Mary Ann A. DeMichele-Sweet, Ph.D., and
Lewis H. Kuller, M.D., Ph.D.

Pages:954–962
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11121815

Abstract
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ObjectiveThe trajectory of cognitive decline in patients with late-onset Alzheimer’s disease varies widely. Genetic variations in CLU, PICALM, and CR1 are associated with Alzheimer’s disease, but it is unknown whether they exert their effects by altering ...

September 2012

Genome-Wide Association Study of Multiplex Schizophrenia Pedigrees

Pages:963–973
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11091423

Abstract
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ObjectiveThe authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs).MethodThe family sample ...

September 2012

Short-Term Tropisetron Treatment and Cognitive and P50 Auditory Gating Deficits in Schizophrenia

Xiang Yang Zhang, M.D., Ph.D.,
Lei Liu, M.D.,
Shaowen Liu, M.D.,
Xiaohong Hong, M.D.,
Da Chun Chen, M.D.,
Mei Hong Xiu, Ph.D.,
Fu De Yang, M.D.,
Zhijun Zhang, M.D., Ph.D.,
Xiangrong Zhang, M.D., Ph.D.,
Therese A. Kosten, Ph.D., and
Thomas R. Kosten, M.D.

Pages:974–981
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11081289

Abstract
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ObjectiveThe α7 nicotinic acetylcholine receptor (nAChR) is associated with cognitive and P50 auditory gating deficits in schizophrenia, and α7 nAChR agonists can potentially reverse these deficits. The authors examined multiple dosages of tropisetron, a ...

September 2012

Studies in Humans and Mice Implicate Neurocan in the Etiology of Mania

Xavier Miró, Ph.D.,
Sandra Meier, M.Sc.,
Marie Luise Dreisow, M.Sc.,
Josef Frank, M.Sc.,
Jana Strohmaier, M.Sc.,
René Breuer, M.Sc.,
Christine Schmäl, M.D.,
Önder Albayram, M.Sc.,
María Teresa Pardo-Olmedilla, M.Sc.,
Thomas W. Mühleisen, Ph.D.,
Franziska A. Degenhardt, M.D.,
Manuel Mattheisen, M.D.,
Iris Reinhard, M.Sc.,
Andras Bilkei-Gorzo, Ph.D.,
Sven Cichon, Ph.D.,
Constanze Seidenbecher, Ph.D.,
Marcella Rietschel, M.D.,
Markus M. Nöthen, M.D., and
Andreas Zimmer, Ph.D.

Pages:982–990
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11101585

Abstract
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ObjectiveGenome-wide association has been reported between the NCAN gene and bipolar disorder. The aims of this study were to characterize the clinical symptomatology most strongly influenced by NCAN and to explore the behavioral phenotype of Ncan ...

Letters to the Editor

September 2012

Protecting Psychiatrists’ Reputations on the Internet

Alan A. Stone, M.D., and
Paul S. Appelbaum, M.D.

Page:991
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050623

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September 2012

Response to Stone and Appelbaum Letter

Glen O. Gabbard, M.D.

Page:991
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050623r

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September 2012

Celiac Disease and Schizophrenia

James S. Brown, Jr., M.D., M.P.H.

Pages:991–992
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12060735

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September 2012

Alternative Interpretation for the Early Detection of Psychosis Study

Andrew Amos, B.ARTS (HONS), M.B.B.S.

Page:992
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050578

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September 2012

Response to Amos Letter

Wenche ten Velden Hegelstad, M.Sc.,
Tor K. Larsen, M.D. Ph.D.,
Jan O. Johannesen, M.D. Ph.D.,

Ingrid Melle, M.D. Ph.D.,

Erik Simonsen, M.D. Ph.D.,

Svein Friis, M.D. Ph.D., and

Thomas McGlashan, M.D.

Pages:992–993
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050578r

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September 2012

Bilateral Pallidal Necrosis and Cardiac Toxicity in a Patient With Venlafaxine and Bupropion Overdose

Yu-Hsuan Lin, M.D.,
Eason Huang, M.D., and
Yi-Ling Chien, M.D.

Pages:993–994
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11111708

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Book Forum

September 2012

The Inseparable Nature of Love and Aggression: Clinical and Theoretical Perspectives

Salman Akhtar, M.D.

Pages:995–996
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050584

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September 2012

Autism Spectrum Disorders

Fred R. Volkmar, M.D.

Page:996
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050583

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September 2012

Women in Psychiatry: Personal Perspectives

Mary Anne Badaracco, M.D.

Pages:996–997
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.12050721

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September 2012

The Origins of Schizophrenia

Dolores Malaspina, M.D., M.S.P.H.

Page:998
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.11121785

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Official Actions

September 2012

Reports to the Membership

Pages:999–1004
Published Online:1 September 2012

https://doi.org/10.1176/appi.ajp.2012.Official

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