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Choline chloride in schizophrenia

Published Online:https://doi.org/10.1176/ajp.136.12.1581

The authors investigated the possibility that choline chloride might reduce schizophrenic symptoms by increasing central cholinergic activity. In a single blind crossover study, up to 20 g/day of choline chloride had no significant effect on clinical ratings of nine schizophrenic patients. However, there was some evidence that choline significantly increased symptoms of depression.

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