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Published Online:https://doi.org/10.1176/ajp.117.10.930

The findings indicate that low-dose akathisia results from an individual's specific sensitivity to a specific molecular configuration. There is a population with a low threshold for the disorder. Thresholds are determined by the spectrum of individual sensitivities for specific molecular configurations, administered in a specified dosage schedule. The incidence and intensity of low-dose akathisia depend on at least 2 factors: the population tested, and specific molecular structure. [SEE TABLE 1 IN SOURCE PDF]

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