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Chapter 64. Psychopharmacology During Pregnancy and Lactation

D. Jeffrey Newport, M.D.; Susana V. Fernandez, B.A.; Sandra Juric, B.A.; Zachary N. Stowe, M.D.
DOI: 10.1176/appi.books.9781585623860.437197

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Excerpt

The management of mental illness during pregnancy and lactation represents a unique and complex clinical situation involving a minimum of two concomitant medical conditions (i.e., pregnancy and a psychiatric disorder) and also demanding consideration of the welfare of at least two patients (i.e., mother and child), not to mention the potential impact of maternal illness on the family at large. The American College of Obstetricians and Gynecologists Practice Bulletin on the use of psychotropic medications during pregnancy and lactation acknowledges the potential adverse impact of untreated or inadequately treated maternal mental illness (American College of Obstetricians and Gynecologists 2007).

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Table Reference Number
TABLE 64–1. Risks of perinatal medication exposure
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TABLE 64–2. U.S. Food and Drug Administration (FDA) use-in-pregnancy ratings
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TABLE 64–3. Antidepressant medications
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TABLE 64–4. Mood-stabilizing and antiepileptic medications
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TABLE 64–5. Antipsychotic medications
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TABLE 64–6. Anxiolytic and hypnotic medications
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TABLE 64–7. Risk–benefit assessment for pregnancy: summary of facts
Table Reference Number
TABLE 64–8. Risk–benefit assessment for lactation: summary of facts

References

Aarskog D: Letter: Association between maternal intake of diazepam and oral clefts. Lancet 2(7941):921, 1975
[PubMed]
 
Adab N, Jacoby A, Smith D, et al: Additional educational needs in children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 70:15–21, 2001
[PubMed]
 
Agatonovic-Kustrin S, Ling LH, Tham SY, et al: Molecular descriptors that influence the amount of drugs transfer into human breast milk. J Pharm Biomed Anal 29:103–119, 2002
[PubMed]
 
Alexander FW: Sodium valproate and pregnancy. Arch Dis Child 54:240, 1979
[PubMed]
 
Allen S: A quantitative analysis of the process, mediating variables, and impact of traumatic childbirth. J Reprod Infant Psychol 16:107–131, 1998
 
Alonso SJ, Navarro E, Rodriguez M: Permanent dopaminergic alterations in the nucleus accumbens after prenatal stress. Pharmacol Biochem Behav 49:353–358, 1994
[PubMed]
 
Alonso SJ, Navarro E, Santana C, et al: Motor lateralization, behavioral despair and dopaminergic brain asymmetry after prenatal stress. Pharmacol Biochem Behav 58:443–448, 1997
[PubMed]
 
Altshuler LL, Burt VK, McMullen M, et al: Breastfeeding and sertraline: a 24-hour analysis. J Clin Psychiatry 56:243–245, 1995
[PubMed]
 
Altshuler LL, Cohen LS, Szuba MP, et al: Pharmacologic management of psychiatric illness in pregnancy: dilemmas and guidelines. Am J Psychiatry 153:592–606, 1996
[PubMed]
 
Alwan S, Reefhuis J, Rasmussen SA, et al: Use of selective serotonin-reuptake inhibitors in pregnancy and the risk of birth defects. N Engl J Med 356:2684–2692, 2007
[PubMed]
 
Ambresin G, Berney P, Schulz P, et al: Olanzapine excretion into breast milk: a case report. J Clin Psychopharmacol 24:93–95, 2004
[PubMed]
 
American Academy of Pediatrics, Committee on Drugs: The transfer of drugs and other chemicals into human milk. Pediatrics 108:776–789, 2001
 
American College of Obstetricians and Gynecologists: ACOG Practice Bulletin No. 87, November 2007: Use of psychiatric medications during pregnancy and lactation. Obstet Gynecol 110:1179–1198, 2007
 
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision. Washington, DC, American Psychiatric Association, 2000
 
Andrade SE, Raebel MA, Brown J, et al: Use of antidepressant medications during pregnancy: a multisite study. Am J Obstet Gynecol 198(2):194.e1–194.e5, 2008
 
Andrews M, Rosenblum L: Relationship between foraging and affiliative social referencing in primates, in Ecology and Behavior of Food-Enhanced Primate Groups. Edited by Fa J, Southwick C. New York, Alan R Liss, 1988, pp 247–268
 
Andrews M, Rosenblum L: Attachment in monkey infants raised in variable and low-demand environments. Child Dev 62:686–693, 1991
[PubMed]
 
Andrews M, Rosenblum L: Developmental consequences of altered dyadic coping patterns in bonnet macaques, in Current Primatology: Social Development, Learning and Behavior. Edited by Roeder J, Thierry B, Anderson J, et al. Strasbourg, France, Universitie Louis Pasteur, 1994, pp 265–271
 
Appleby L, Warner R, Whitton A, et al: A controlled study of fluoxetine and cognitive-behavioral counseling in the treatment of postnatal depression. BMJ 314:932–936, 1997
[PubMed]
 
Ardinger H, Atkin J, Blackston RD, et al: Verification of the fetal valproate syndrome phenotype. Am J Med Genet 29:171–185, 1988
[PubMed]
 
Assencio-Ferreira VJ, Abraham R, Veiga JC, et al: Metopic suture craniosynostosis: sodium valproate teratogenic effect: case report [Portuguese]. Arquivos de Neuro-Psiquiatria 59(2-B):417–420, 2001
 
Athinarayanan P, Peirog SH, Nigam SK, et al: Chlordiazepoxide withdrawal in the neonate. Am J Obstet Gynecol 124:212–213, 1976
[PubMed]
 
Atkinson HC, Begg EJ, Darlow BA: Drugs in human milk: clinical pharmacokinetic considerations. Clin Pharmacokinet 14:217–240, 1988
[PubMed]
 
Audus KL: Controlling drug delivery across the placenta. Eur J Pharmacol Sci 8:161–165, 1999
[PubMed]
 
Backes CR, Cordero L: Withdrawal symptoms in the neonate from presumptive intrauterine exposure to diazepam: report of case. J Am Osteopath Assoc 79:584–585, 1980
[PubMed]
 
Bardy AH, Granström ML, Hiilesmaa VK: Valproic acid and breast feeding, in Epilepsy, Pregnancy, and the Child. Edited by Janz D, Dam M, Richens A. New York, Raven Press 1982a, pp 359–360
 
Bardy AH, Teramo K, Hiilesmaa VK: Apparent plasma clearances of phenytoin, phenobarbitone, primidone, and carbamazepine during pregnancy: results of the prospective Helsinki study, in Epilepsy, Pregnancy, and the Child. Edited by Janz D, Dam M, Richens A, et al. New York, Raven Press, 1982b, pp 141–145
 
Barnas C, Bergant A, Hummer A, et al: Clozapine concentrations in maternal and fetal plasma, amniotic fluid, and breast milk. Am J Psychiatry 151:945, 1994
[PubMed]
 
Barry WS, St. Clair SM: Exposure to benzodiazepines in utero. Lancet 1(8547):1436–1437, 1987
[PubMed]
 
Barson AJ: Malformed infants. BMJ 2:45, 1972
[PubMed]
 
Battino D, Avanzini G, Bossi L, et al: Monitoring of antiepileptic drug plasma levels during pregnancy and puerperium, in Epilepsy, Pregnancy, and the Child. Edited by Janz D, Dam M, Richens A, et al. New York, Raven Press, 1982, pp 147–154
 
Bennedsen BE, Mortensen PB, Olesen AV, et al: Obstetric complications in women with schizophrenia. Schizophr Res 47:167–175, 2001
[PubMed]
 
Bergman U, Rosa FW, Baum C, et al: Effects of exposure to benzodiazepine during fetal life. Lancet 340:694–696, 1992
[PubMed]
 
Bertossi M, Virgintino D, Errede M, et al: Immunohistochemical and ultrastructural characterization of cortical plate microvasculature in the human fetus telencephalon. Microvasc Res 58:49–61, 1999
[PubMed]
 
Bescoby-Chambers N, Forster P, Bates G: Foetal valproate syndrome and autism: additional evidence of an association. Dev Med Child Neurol 43:847, 2001
[PubMed]
 
Birnbaum C, Cohen LS, Bailey JW, et al: Serum concentrations of antidepressants and benzodiazepines in nursing infants: a case series. Pediatrics 104:1–6, 1999
 
Bitnum S: Possible effects of chlordiazepoxide on the foetus. Can Med Assoc J 100:351, 1969
 
Bjerkedal T, Czeizel A, Goujard J, et al: Valproic acid and spina bifida. Lancet 2(8307):109, 1982
 
Black MM, Matula K: Essentials of Bayley Scales of Infant Development—II Assessment. New York, Wiley, 2000
 
Bledsoe SE, Grote NK: Treating depression during pregnancy and the postpartum: a preliminary meta-analysis. Res Soc Work Pract 16:109–120, 2006
 
Blehar MC, DePaulo JR, Gershon ES, et al: Women with bipolar disorder: findings from the NIMH Genetics Initiative sample. Psychopharmacol Bull 34:239–243, 1998
[PubMed]
 
Bologa M, Tang B, Klein J, et al: Pregnancy-induced changes in drug metabolism in epileptic women. J Pharmacol Exp Ther 267:735–740, 1991
 
Boobis AR, Lewis PJ: Pharmacokinetics in pregnancy, in Clinical Pharmacology in Obstetrics. Edited by Lewis P. Boston, MA, Wright-PSG, 1983, pp 6–54
 
Boshier A, Wilton LV, Shakir SA: Evaluation of the safety of bupropion (Zyban) for smoking cessation from experience gained in general practice use in England in 2000. Eur J Clin Pharmacol 59:767–773, 2003
[PubMed]
 
Brent NB, Wisner KL: Fluoxetine and carbamazepine concentrations in a nursing mother/infant pair. Clin Pediatr 37:41–44, 1998
[PubMed]
 
Briggs GG, Samson JH, Ambrose PJ, et al: Excretion of bupropion in breast milk. Ann Pharmacother 27:431–433, 1993
[PubMed]
 
Briggs GG, Freeman RK, Yaffe SJ: Drugs in Pregnancy and Lactation, 4th Edition. Philadelphia, PA, Lippincott Williams & Wilkins, 1994
 
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation, 7th Edition. Philadelphia, PA, Lippincott Williams & Wilkins, 2005
 
Bucove AD: A case of prepartum psychosis and infanticide. Psychiatr Q 42:263–270, 1968
[PubMed]
 
Buesching DP, Glasser ML, Frate DA: Progression of depression in the prenatal and postpartum periods. Women Health 11:61–78, 1988
 
Buist A, Norman TR, Dennerstein L: Breastfeeding and the use of psychotropic medication: a review. J Affect Disord 19:197–206, 1990
[PubMed]
 
Burch K, Wells B: Fluoxetine/norfluoxetine concentrations in human milk. Pediatrics 89:676–677, 1992
[PubMed]
 
Canger R, Battino D, Canevini MP, et al: Malformations in offspring of women with epilepsy: a prospective study. Epilepsia 40:1231–1236, 1999
[PubMed]
 
Casper RC, Fleisher BE, Lee-Ancajas JC, et al: Follow-up of children of depressed mothers exposed or not exposed to antidepressant drugs during pregnancy. J Pediatr 142:402–408, 2003
[PubMed]
 
Cassels C: Valproate should not be used as first-line therapy in women of childbearing age. Medscape Today. Medscape Medical News. August 7, 2006. Available at: http://www.medscape.com/viewarticle/542424. Accessed March 2008.
 
Centers for Disease Control: Spina bifida incidence at birth—United States, 1983–1990. MMWR Morb Mortal Wkly Rep 41:497–500, 1992
 
Chambers CD, Johnson KA, Dick LM, et al: Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 335:1010–1015, 1996
[PubMed]
 
Chambers CD, Hernandez-Diaz S, Van Marter LJ, et al: Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N Engl J Med 354:579–587, 2006
[PubMed]
 
Chun-Fai-Chan B, Koren G, Fayez I, et al: Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 192:932–936, 2005
[PubMed]
 
Clarke AS, Schneider ML: Prenatal stress has long-term effects on behavioral responses to stress in juvenile rhesus monkeys. Dev Psychobiol 26:293–304, 1993
[PubMed]
 
Cleary MF: Fluphenazine decanoate during pregnancy. Am J Psychiatry 134:815–816, 1977
[PubMed]
 
Cohen LS, Heller VL, Rosenbaum JF: Treatment guidelines for psychotropic drug use in pregnancy. Psychosomatics 30:25–33, 1989
[PubMed]
 
Cohen LS, Friedman JM, Jefferson JW, et al: A reevaluation of risk of in utero exposures to lithium. JAMA 271:146–150, 1994
[PubMed]
 
Cohen LS, Altshuler LL, Harlow BL, et al: Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment. JAMA 295:499–507, 2006 [Erratum in JAMA 296:170, 2006]
 
Cole JA, Ephross SA, Cosmatos IS, et al: Paroxetine in the first trimester and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf 16:1075–1085, 2007
[PubMed]
 
Coons PM, Ascher-Svanum H, Bellis K: Self-amputation of the female breast. Psychosomatics 27:667–668, 1986
[PubMed]
 
Coplan J, Andrews M, Rosenblum LA, et al: Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci U S A 93:1619–1623, 1996
[PubMed]
 
Coplan J, Trost R, Owens M, et al: Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions. Arch Gen Psychiatry 55:473–477, 1998
[PubMed]
 
Coppola D, Russo LJ, Kwarta RF, et al: Evaluating the postmarketing experience of risperidone use during pregnancy: pregnancy and neonatal outcomes. Drug Saf 30:247–264, 2007
[PubMed]
 
Costei AM, Kozer E, Ho T, et al: Perinatal outcome following third trimester exposure to paroxetine. Arch Pediatr Adolesc Med 156:1129–1132, 2002
[PubMed]
 
Cox MT, Stowe ZN, Hostetter A, et al: Cortisol concentrations in the breast milk of women with major depression. Paper presented at the American Psychiatric Association 153rd Annual Meeting, Chicago, IL, May 13–18, 2000
 
Croke S, Buist A, Hackett LP, et al: Olanzapine excretion in human breast milk: estimation of infant exposure. Int J Neuropsychopharmacol 5:243–247, 2002
[PubMed]
 
Cutrona CE: Causal attributions and perinatal depression. J Abnorm Psychol 92:161–172, 1986
 
Dalens B, Raynaud EJ, Gaulme J: Teratogenicity of valproic acid. J Pediatr 97:332–333, 1980
[PubMed]
 
Dallemagne G, Weiss B: Altered behavior of mice following postnatal treatment with haloperidol. Pharmacol Biochem Behav 16:761–767, 1982
[PubMed]
 
Dam J, Christiansen J, Munck O, et al: Antiepileptic drugs: metabolism in pregnancy. Clin Pharmacokinet 4:53–62, 1979
[PubMed]
 
Davison JM, Hytten FE: Glomerular filtration during and after pregnancy. Br J Obstet Gynaecol 81:588–595, 1974
[PubMed]
 
Dean JC, Moore SJ, Osborne A, et al: Fetal anticonvulsant syndrome and mutation in the maternal MTHFR gene. Clin Genet 56:216–220, 1999
[PubMed]
 
de Haan GJ, Edelbroek P, Segers J, et al: Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study. Neurology 63:571–573, 2004
 
Dev V, Krupp P: The side-effects and safety of clozapine. Rev Contemp Pharmacother 6:197–208, 1995
 
Di Liberti JH, Farndon PA, Dennis NR, et al: The fetal valproate syndrome. Am J Med Genet 19:473–481, 1984
 
Di Michele V, Ramenghi LA, Sabatino G: Clozapine and lorazepam administration in pregnancy. Eur Psychiatry 11:214, 1996
 
Dickinson RG, Harland RC, Lynn RK, et al: Transmission of valproic acid (Depakene) across the placenta: half-life of the drug in mother and baby. J Pediatr 94 832–835, 1979
 
Dickson RA, Edwards A: Clozapine and fertility. Am J Psychiatry 154:582–583, 1997
[PubMed]
 
Dickson RA, Hogg L: Pregnancy of a patient treated with clozapine. Psychiatr Serv 49:1081–1083, 1998
[PubMed]
 
Djulus J, Koren G, Einarson TR, et al: Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes. J Clin Psychiatry 67:1280–1284, 2006
[PubMed]
 
Dodd S, Stocky A, Buist A, et al: Sertraline in paired blood plasma and breast-milk samples from nursing mothers. Hum Psychopharmacol 15:261–264, 2000
 
Doering JC, Stewart RB: The extent and character of drug consumption during pregnancy. JAMA 239:843–846, 1978
[PubMed]
 
Dolk H, Jentink J, Loane M, et al: Does Lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 71:714–722, 2008
[PubMed]
 
Dominguez-Salgado M, Morales A, Santiago Gomez R, et al: Gestational lamotrigine monotherapy: congenital malformations and psychomotor development (abstract). Epilepsia 45 (suppl 7):229–230, 2004
 
Downey G, Coyne JC: Children of depressed parents: an integrative review. Psychol Bull 108:50–76, 1990
[PubMed]
 
Duffy CL: Postpartum depression: identifying women at risk. Genesis 11:21, 1983
 
Dunlop W: Serial changes in renal haemodynamics during pregnancy. Br J Obstet Gynaecol 8:1–9, 1981
 
Ebbesen F, Joergensen AM, Hoseth E, et al: Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate. Arch Dis Child Fetal Neonatal Ed 83:F124–F129, 2000
 
Edlund MJ, Craig TJ: Antipsychotic drug use and birth defects: an epidemiologic reassessment. Compr Psychiatry 25:244–248, 1976
 
Eggermont E: Withdrawal symptoms in neonates associated with maternal imipramine therapy. Lancet 2(7830):680, 1973
[PubMed]
 
Einarson A, Fatoye B, Sarkar M, et al: Pregnancy outcome following gestational exposure to venlafaxine: a multicenter prospective controlled study. Am J Psychiatry 158:1728–1730, 2001
[PubMed]
 
Einarson A, Bonari L, Voyer-Lavigne S, et al: A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy. Can J Psychiatry 48:106–110, 2003
[PubMed]
 
Elia J, Katz IR, Simpson GM: Teratogenicity of psychotherapeutic medications. Psychopharmacol Bull 23:531–586, 1987
[PubMed]
 
Entman SS, Vaughn WK: Lack of relation of oral clefts to diazepam use in pregnancy. N Engl J Med 310:1121–1122, 1984
[PubMed]
 
Epperson C, Anderson G, McDougle C: Sertraline and breast-feeding. N Engl J Med 336:1189–1190, 1997
[PubMed]
 
Epperson N, Czarkowski KA, Ward-O'Brien D, et al: Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs. Am J Psychiatry 158:1631–1637, 2001
[PubMed]
 
Ericson A, Kallen B, Wiholm BE: Delivery outcome after the use of antidepressants in early pregnancy. Eur J Clin Pharmacol 55:503–508, 1999
[PubMed]
 
Erkkola R, Kanto J, Sellman R: Diazepam in early human pregnancy. Acta Obstet Gynecol Scand 53:135–138, 1974
[PubMed]
 
Erkkola R, Kero P, Kanto J, et al: Severe abuse of psychotropic drugs during pregnancy with good perinatal outcome. Ann Clin Res 15:88–91, 1983
[PubMed]
 
Eros E, Czeizel AE, Rockenbauer M, et al: A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolam, and clonazepam treatment during pregnancy. Eur J Obstet Gynecol Reprod Biol 101:147–154, 2002
[PubMed]
 
Falterman CG, Richardson CJ: Small left colon syndrome associated with maternal ingestion of psychotropic drugs. J Pediatr 97:308–310, 1980
[PubMed]
 
Fisher AD, Brown JS, Newport DJ, et al: Fetal CNS exposure after maternal SSRI: a rodent model (NR137), in 2001 New Research Program and Abstracts, American Psychiatric Association 154th Annual Meeting, New Orleans, LA, May 5–10, 2001. Washington, DC, American Psychiatric Association, 2001, p 12
 
Fisher JN, Edgren BE, Mammel MC, et al: Neonatal apnea associated with clonazepam therapy: a case report. Obstet Gynecol 66:348–358, 1985
[PubMed]
 
Fones C: Posttraumatic stress disorder occurring after painful childbirth. J Nerv Ment Dis 184:195–196, 1996
[PubMed]
 
Frederiksen MC: Physiologic changes in pregnancy and their effect on drug disposition. Semin Perinatol 25:120–123, 2001
[PubMed]
 
Frederiksen MC, Ruo TI, Chow MJ, et al: Theophylline pharmacokinetics in pregnancy. Clin Pharmacol Ther 40:321–328, 1986
[PubMed]
 
Freeman MP, Smith KW, Freeman SA, et al: The impact of reproductive events on the course of bipolar disorder in women. J Clin Psychiatry 63:284–287, 2000
 
Frey B, Schubiger G, Musy JP: Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding. Eur J Pediatr 150:136–138, 1990
[PubMed]
 
Frey B, Braegger CP, Ghelfi D: Neonatal cholestatic hepatitis from carbamazepine exposure during pregnancy and breast feeding. Ann Pharmacother 36:644–647, 2002
[PubMed]
 
Fride E, Weinstock M: The effects of prenatal exposure to predictable or unpredictable stress on early development in the rat. Dev Psychobiol 17:651–660, 1984
[PubMed]
 
Fride E, Weinstock M: Prenatal stress increases anxiety related behavior and alters cerebral lateralization of dopamine activity. Life Sci 36:1059–1065, 1988
 
Fride E, Dan Y, Gavish M, et al: Prenatal stress impairs maternal behavior in a conflict situation and reduces hippocampal benzodiazepine receptors. Life Sci 36:2103, 1985
[PubMed]
 
Fride E, Dan Y, Feldon J, et al: Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats. Physiol Behav 37:681–687, 1986
[PubMed]
 
Frieder B, Epstein S, Grimm VE: The effects of exposure to diazepam during various stages of gestation or during lactation on the development and behavior of rat pups. Psychopharmacology 83:51–55, 1984
[PubMed]
 
Friedman JM, Polifka JE: Teratogenic Effects of Drugs: A Resource for Clinicians (TERIS), 2nd Edition. Baltimore, MD, Johns Hopkins University Press, 2000, pp ix–x
 
Friedman SH, Rosenthal MB: Treatment of perinatal delusional disorder: a case report. Int J Psychiatry Med 33:391–394, 2003
[PubMed]
 
Fries H: Lithium in pregnancy. Lancet 1(7658):1233, 1970
[PubMed]
 
Froescher W, Eichelbaum M, Nieson M, et al: Antiepileptic therapy with carbamazepine and valproic acid during pregnancy and the lactation period, in Advances in Epileptology: The 12th Epilepsy International Symposium. Edited by Dam M, Gram L, Penry JK. New York, Raven Press, 1981, pp 581–588
 
Froescher W, Eichelbaum M, Niesen M, et al: Carbamazepine levels in breast milk. Ther Drug Monit 6:266–271, 1984a
 
Froescher W, Gugler R, Niesen M, et al: Protein binding of valproic acid in maternal and umbilical cord serum. Epilepsia 25:244–249, 1984b
 
Fujioka T, Sakata Y, Yamaguchi K, et al: The effects of prenatal stress on the development of hypothalamic paraventricular neurons in fetal rats. Neuroscience 92:1079–1088, 1999
[PubMed]
 
Gaily E, Kantola-Sorsa E, Granstrom ML: Specific cognitive dysfunction in children with epileptic mothers. Dev Med Child Neurol 32:403–414, 1990
[PubMed]
 
Gaily E, Kantola-Sorsa E, Hiilasmaa V et al: Normal intelligence in children with prenatal exposure to carbamazepine. Neurology 62:8–9, 2004
 
Galler JR, Harrison RH, Ramsey F, et al: Maternal depressive symptoms affect infant cognitive development in Barbados. J Child Psychol Psychiatry 41:747–757, 2000
[PubMed]
 
Gardiner SJ, Kristensen JH, Begg EJ, et al: Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants. Am J Psychiatry 160:1428–1431, 2003
[PubMed]
 
Gerhardsson M, Alfredsson L: In-utero exposure to benzodiazepines. Lancet 1(8533):628, 1987
 
GlaxoSmithKline: Epidemiology study: Updated preliminary report on bupropion and other antidepressants, including paroxetine in pregnancy and the occurrence of cardiovascular and major congenital malformations (study EPIP083). 2005. Available at: http://ctr.gsk.co.uk/summary/paroxetine/epip083part2.pdf. Accessed January 2008.
 
GlaxoSmithKline Corp: International Pregnancy Registry: interim report (1 September 1992 through 31 March 2007). Wilmington, NC, Inveresk, 2007
 
Glaze R, Chapman G, Murray D: Recurrence of puerperal psychosis during late pregnancy. Br J Psychiatry 159:567–569, 1991
[PubMed]
 
Goldberg HL, DiMascio A: Psychotropic drugs in pregnancy, in Psychopharmacology: A Generation of Progress. Edited by Lipton HL, DiMascio A, Killam KF. New York, Raven, 1978, pp 1047–1055
 
Goldstein DJ, Sundell KL, Corbin LA: Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 336:872–873, 1997
[PubMed]
 
Goldstein DJ, Corbin LA, Fung MC: Olanzapine-exposed pregnancies and lactation: early experience. J Clin Psychopharmacol 20:399–403, 2000
[PubMed]
 
Graybeal S, Newport DJ, Fisher A, et al: Antidepressants in pregnancy, minimizing fetal exposure: clinical and preclinical data (NR280), in 2002 New Research Program and Abstracts, American Psychiatric Association 155th Annual Meeting, Philadelphia, PA, May 18–23, 2002. Washington, DC, American Psychiatric Association, 2002, p 25
 
Greenough A, Khetriwal B: Pulmonary hypertension in the newborn. Paediatr Respir Rev 6:111–116, 2005
[PubMed]
 
Grof PR, Robbins W, Alda M, et al: Protective effect of pregnancy in women with lithium-responsive bipolar disorder. J Affect Disord 61:31–39, 2000
[PubMed]
 
Hakkola J, Pasanen M, Hukkanen J, et al: Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem Pharmacol 51:403–411, 1996
[PubMed]
 
Hallberg P, Sjöblom V: The use of selective serotonin reuptake inhibitors during pregnancy and breast-feeding: a review and clinical aspects. J Clin Psychopharmacol 25:59–73, 2005
[PubMed]
 
Hannah P, Adams D, Glover V, et al: Abnormal platelet 5-hydroxytryptamine uptake and imipramine binding in postnatal dysphoria. J Psychiatr Res 26:69–75, 1992
[PubMed]
 
Haram K: "Floppy infant syndrome" and maternal diazepam. Lancet 2(8038):612–613, 1977
[PubMed]
 
Hartz SC, Heinonen OP, Shapiro S, et al: Antenatal exposure to meprobamate and chlordiazepoxide in relation to malformations, mental development, and childhood mortality. N Engl J Med 292:726–728, 1975
[PubMed]
 
Hassmannova J, Myslivecek J: Inhibitory and excitatory adult learning after prenatal diazepam application. Studia Psychologica 36:323–326, 1994
 
Hayashi A, Nagaoka M, Yamada K, et al: Maternal stress induces synaptic loss and developmental disabilities of offspring. Int J Dev Neurosci 16:209–216, 1998
[PubMed]
 
Hedegaard M, Henriksen T, Sabroe S, et al: The relationship between psychological distress during pregnancy and birth weight for gestational age. Acta Obstet Gynecol Scand 75:32–39, 1996
[PubMed]
 
Heikkinen T, Ekblad U, Kero P, et al: Citalopram in pregnancy and lactation. Clin Pharmacol Ther 72:184–191, 2002
[PubMed]
 
Heinonen OP, Stone D, Shapiro S: Birth Defects and Drugs in Pregnancy. Littleton, MA, Publishing Sciences Group, 1977
 
Hendrick V, Fukuchi A, Altshuler LL, et al: Use of sertraline, paroxetine, and fluvoxamine by nursing women. Br J Psychiatry 179:163–166, 2001
[PubMed]
 
Hendrick V, Smith LM, Suri R, et al: Birth outcomes after prenatal exposure to antidepressant medication. Am J Obstet Gynecol 188:812–815, 2003a
 
Hendrick V, Stowe ZN, Altshuler LL, et al: Placental passage of antidepressant medication. Am J Psychiatry 160:993–996, 2003b
 
Henry C, Kabbaj M, Simon H, et al: Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats. J Neuroendocrinol 6:341–345, 1994
[PubMed]
 
Henry C, Guegant G, Cador M, et al: Prenatal stress in rats facilitates amphetamine-induced sensitization and induces long-lasting changes in dopamine receptors in the nucleus accumbens. Brain Res 685:179–186, 1995
[PubMed]
 
Hernandez-Diaz S, Werler MM, Walker AM, et al: Neural tube defects in relation to use of folic acid antagonists during pregnancy. Am J Epidemiol 153:961–968, 2001
[PubMed]
 
Herrenkohl LR, Gala RR: Serum prolactin levels and maintenance of progeny by prenatally stressed female offspring. Experientia 35:702–704, 1979
[PubMed]
 
Hertzberg T, Wahlbeck K: The impact of pregnancy and puerperium on panic disorder: a review. J Psychosom Obstet Gynecol 20:59–64, 1999
[PubMed]
 
Hill RC, McIvor RJ, Wojnar-Horton RE, et al: Risperidone distribution and excretion into human milk: case report and estimated infant exposure during breast-feeding. J Clin Psychopharmacol 20:285–286, 2000
[PubMed]
 
Hill RM, Stern L: Drugs in pregnancy: effects on the fetus and newborn. Curr Ther 20:131–150, 1979
 
Hill RM, Desmond MM, Kay JL: Extrapyramidal dysfunction in an infant of a schizophrenic mother. J Pediatr 69:589–595, 1966
[PubMed]
 
Hirsch MS, Swartz MN: Antiviral agents. N Engl J Med 302:903–907, 1980
[PubMed]
 
Hoffeld DR, McNew J, Webster RL: Effect of tranquilizing drugs during pregnancy on activity of offspring. Nature 218:357–358, 1968
[PubMed]
 
Holmes LB, Wyszynski DF, Baldwin EJ, et al: Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy (abstract). Birth Defects Res Part A Clin Mol Teratol 76:318, 2006
 
Homma M, Beckerman K, Hayashi S, et al: Liquid chromatographic determination of urinary 6-hydroxycortisol to assess cytochrome P450 3A activity in HIV positive pregnant women. J Pharm Biomed Anal 23:629–635, 2000
[PubMed]
 
Hostetter A, Ritchie JC, Stowe ZN: Amniotic fluid and umbilical cord blood concentrations of antidepressants in three women. Biol Psychiatry 48:1032–1034, 2000
[PubMed]
 
Hunt JN, Murray FA: Gastric function in pregnancy. Br J Obstet Gynaecol 65:78–83, 1958
[PubMed]
 
Ilett K, Hackett L, Dusci L, et al: Distribution and excretion of venlafaxine and O-desmethylvenlafaxine in human milk. Br J Clin Pharmacol 45:459–462, 1998
[PubMed]
 
Ilett KF, Hackett LP, Kristensen JH, et al: Transfer of risperidone and 9-hydroxyrisperidone into human milk. Ann Pharmacother 38:273–276, 2004
[PubMed]
 
Jacobsen SJ, Jones K, Johnson K, et al: Prospective multicentre study of pregnancy outcome after lithium exposure during first trimester. Lancet 339:530–533, 1992
 
Jager-Roman E, Deichl A, Jakob S, et al: Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid. J Pediatr 108:997–1004, 1986
[PubMed]
 
Jaiswal A, Bhattacharya S: Effects of gestational undernutrition, stress and diazepam treatment on spatial discrimination learning and retention in young rats. Indian J Exp Biol 31:353–359, 1993
[PubMed]
 
James ME: Neuroleptic malignant syndrome in pregnancy. Psychosomatics 29:112–119, 1988
 
Jameson PB, Gelfand DM, Kulcsar E, et al: Mother-toddler interaction patterns associated with maternal depression. Dev Psychopathol 9:537–550, 1997
[PubMed]
 
Jenike MA, Hyman S, Baer L, et al: A controlled trial of fluvoxamine in obsessive-compulsive disorder: implications for a serotonergic theory. Am J Psychiatry 147:1209–1215, 1990
[PubMed]
 
Jensen P, Olesen O, Bertelsen A, et al: Citalopram and desmethylcitalopram concentrations in breast milk and in serum of mother and infant. Ther Drug Monit 19:236–239, 1997
[PubMed]
 
Jones KL, Lacro RV, Johnson KA, et al: Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N Engl J Med 320:1661–1666, 1989
[PubMed]
 
Källén B: Neonate characteristics after maternal use of antidepressants in late pregnancy. Arch Pediatr Adolesc Med 158:312–316, 2004
[PubMed]
 
Källén B, Tandberg A: Lithium and pregnancy: a cohort of manic-depressive women. Acta Psychiatr Scand 68:134–139, 1983
[PubMed]
 
Kaneko S, Suzuki K, Sato T, et al: The problems of antiepileptic medication in the neonatal period: is breast-feeding advisable? in Epilepsy, Pregnancy and the Child. Edited by Janz D, Dam M, Richens A. New York, Raven Press, 1982, pp 343–348
 
Kaneko S, Battino D, Andermann E, et al: Congenital malformations due to antiepileptic drugs. Epilepsy Res 33:145–158, 1999
[PubMed]
 
Kaplan B, Modai I, Stoler M, et al: Clozapine treatment and risk of unplanned pregnancy. J Am Board Fam Pract 8:239–241, 1996
 
Kaplan HI, Sadock BJ: Pocket Handbook of Psychiatric Drug Treatment. Baltimore, MD, Williams & Wilkins, 1993
 
Kari FW, Weaver R, Neville MC: Active transport of nitrofurantoin across the mammillary epithelium in vivo. J Pharmacol Exp Ther 280:664–668, 1997
[PubMed]
 
Karlsson K, Lindstedt G, Lundberg PA, et al: Letter: Transplacental lithium poisoning: reversible inhibition of fetal thyroid. Lancet 1(7919):1295, 1975
[PubMed]
 
Kendell R, Chalmers J, Platz C: Epidemiology of puerperal psychosis. Br J Psychiatry 150:662–673, 1987
[PubMed]
 
Kendler KS, Kessler RC, Neale MC, et al: The prediction of major depression in women: toward an integrated etiologic model. Am J Psychiatry 150:1139–1148, 1993
[PubMed]
 
Kennedy D, Koren G: Valproic acid use in psychiatry: issues in treating women of reproductive age. J Psychiatry Neurosci 23:223–228, 1998
[PubMed]
 
Kerns LL: Treatment of mental disorders in pregnancy: a review of psychotropic drug risks and benefits. J Nerv Ment Dis 174:652–659, 1986
[PubMed]
 
Kiely M: Reproductive and Perinatal Epidemiology. Boca Raton, FL, CRC Press, 1991
 
Kirchheiner J, Berghofer A, Bolk-Weischedel D: Healthy outcome under olanzapine treatment in a pregnant woman. Pharmacopsychiatry 33:78–80, 2000
[PubMed]
 
Kirksey A, Groziak SM: Maternal drug use: evaluation of risks to breast-fed infants. World Rev Nutr Diet 43:60–79, 1984
[PubMed]
 
Koch S, Jager-Roman E, Rating D, et al: Possible teratogenic effect of valproate during pregnancy. J Pediatr 103:1007–1008, 1983
[PubMed]
 
Kok TH, Taitz LS, Bennett MJ, et al: Drowsiness due to clemastine transmitted in breast milk. Lancet 1(8277):914–915, 1982
[PubMed]
 
Korebrits C, Ramirez M, Watson L, et al: Maternal corticotropin-releasing hormone is increased with impending preterm birth. J Clin Endocrinol Metab 83:1585–1591, 1998
[PubMed]
 
Kornhuber J, Weller M: Postpartum psychosis and mastitis: a new indication for clozapine? Am J Psychiatry 148:1751–1752, 1991
[PubMed]
 
Kozma C: Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. Am J Med Genet 98:168–175, 2001
[PubMed]
 
Kriel RL, Cloyd J: Clonazepam and pregnancy. Ann Neurol 11:544, 1982
[PubMed]
 
Kris EB: Children of mothers maintained on pharmacotherapy during pregnancy and postpartum. Curr Ther Res 7:785–789, 1965
[PubMed]
 
Kris EB, Carmichael D: Chlorpromazine maintenance therapy during pregnancy and confinement. Psychiatr Q 31:690–695, 1957
[PubMed]
 
Kristensen J, Ilett K, Dusci L, et al: Distribution and excretion of sertraline and N-desmethylsertraline in human milk. Br J Clin Pharmacol 45:453–457, 1998
[PubMed]
 
Kristensen J, Ilett K, Hackett L, et al: Distribution and excretion of fluoxetine and norfluoxetine in human milk. Br J Clin Pharmacol 48:521–527, 1999
[PubMed]
 
Kuhnz W, Jager-Roman E, Rating D, et al: Carbamazepine and carbamazepine-10,11-epoxide during pregnancy and postnatal period in epileptic mothers and their nursed infants: pharmacokinetics and clinical effects. Pediatr Pharmacol 3:199–208, 1983
[PubMed]
 
Kulin N, Pastuszak A, Sage S, et al: Pregnancy outcome following maternal use of the new selective serotonin reuptake inhibitors: a prospective controlled multicenter study. JAMA 279:609–610, 1998
[PubMed]
 
Kumar R, Robson KM: A prospective study of emotional disorders in childbearing women. Br J Psychiatry 144:35–47, 1984
[PubMed]
 
Laegreid L, Olegard R, Wahlstrom J, et al: Abnormalities in children exposed to benzodiazepines in utero. Lancet 1(8524):108–109, 1987
[PubMed]
 
Laine K, Heikkinen T, Ekblad U, et al: Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations. Arch Gen Psychiatry 60:720–726, 2003
[PubMed]
 
Lajeunie E, Le Merrer M, Marchac D, et al: Syndromal and nonsyndromal primary trigonocephaly: analysis of 237 patients. Am J Med Genet 75:211–215, 1998
[PubMed]
 
Lajeunie E, Barcik U, Thorne JA, et al: Craniosynostosis and fetal exposure to sodium valproate. J Neurosurg 95:778–782, 2001
[PubMed]
 
Lander CM, Livingstone I, Tyrer JH, et al: The clearance of anticonvulsant drugs in pregnancy. Clin Exp Neurol 17:71–78, 1980
 
Lee A, Giesbrecht E, Dunn E, et al: Excretion of quetiapine in breast milk. Am J Psychiatry 161:1715–1716, 2004
[PubMed]
 
Lees MM, Taylor SH, Scott DM, et al: A study of cardiac output at rest throughout pregnancy. Br J Obstet Gynaecol 74:319–328, 1967
[PubMed]
 
Lester B, Cucca J, Andreozzi L, et al: Possible association between fluoxetine hydrochloride and colic in an infant. J Am Acad Child Adolesc Psychiatry 32:1253–1255, 1993
[PubMed]
 
Levine S: Maternal and environmental influences on the adrenocortical response to stress in weanling rats. Science 156:258–260, 1967
[PubMed]
 
Lindhout D, Schmidt D: In-utero exposure to valproate and neural tube defects. Lancet 1(8494):329–333, 1986
 
Liporace J, Kao A, D'Abreu A: Concerns regarding lamotrigine and breast-feeding. Epilepsy Behav 5:102–105, 2004
[PubMed]
 
Little BB: Pharmacokinetics during pregnancy: evidence-based maternal dose formulation. Obstet Gynecol 93:858–868, 1999
[PubMed]
 
Llewellyn AM, Stowe ZN, Nemeroff CB: Infant outcome after sertraline exposure, in 1997 New Research Program and Abstracts, American Psychiatric Association 150th Annual Meeting, San Diego, CA, May 17–22, 1997. Washington, DC, American Psychiatric Association, 1997, p 176
 
Llewellyn AM, Stowe ZN, Strader JR: The use of lithium and management of women with bipolar disorder during pregnancy and lactation. J Clin Psychiatry 59 (suppl 6):57–64, 1998
 
Lou HC, Hansen D, Nordentoft M, et al: Prenatal stressors of human life affect fetal brain development. Dev Med Child Neurol 36:826–832, 1994
[PubMed]
 
Louik C, Lin AE, Werler MM, et al: First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects. N Engl J Med 356:2675–2683, 2007
[PubMed]
 
Lund CV, Donovan JC: Blood volume during pregnancy: significance of plasma and red cell volumes. Am J Obstet Gynecol 98:394–403, 1967
[PubMed]
 
Lundy BL, Jones NA, Field T, et al: Prenatal depression effects on neonates. Infant Behav Dev 22:119–129, 1999
 
Luoma I, Tamminen T, Kaukonen P, et al: Longitudinal study of maternal depressive symptoms and child well-being. J Am Acad Child Adolesc Psychiatry 40:1367–1374, 2001
[PubMed]
 
Luoma I, Kaukonen P, Mäntymaa M, et al: A longitudinal study of maternal depressive symptoms, negative expectations and perceptions of child problems. Child Psychiatry Hum Dev 35:37–53, 2004
[PubMed]
 
Lyons-Ruth K, Wolfe R, Lyubchik A: Depression and the parenting of young children: making the case for early preventive mental health services. Harv Rev Psychiatry 8:148–153, 2000
[PubMed]
 
Maina G, Albert U, Bogetto F, et al: Recent life events and obsessive-compulsive disorder (OCD): the role of pregnancy/delivery. Psychiatry Res 89(1):49–58, 1999
[PubMed]
 
Mammen O, Perel JM, Rudolph G, et al: Sertraline and norsertraline levels in three breastfed infants. J Clin Psychiatry 58:100–103, 1997
[PubMed]
 
Mandelli M, Morselli PL, Nordio S, et al: Placental transfer of diazepam and its disposition in the newborn. Clin Pharmacol Ther 17:564–572, 1975
[PubMed]
 
Manly PC, McMahon RJ, Bradley CF, et al: Depressive attributional style and depression following childbirth. J Abnorm Psychol 91:245–254, 1982
[PubMed]
 
Marcus SM, Flynn HA, Blow FC, et al: Depressive symptoms among pregnant women screened in obstetrics settings. J Womens Health (Larchmt) 12:373–380, 2003
[PubMed]
 
Martinez A, Malphurs J, Field T, et al: Depressed mothers' and their infants' interactions with nondepressed partners. Infant Ment Health J 17:74–80, 1996
 
Martinez-Frias ML: Clinical manifestation of prenatal exposure to valproic acid using case reports and epidemiologic information. Am J Med Genet 37:277–282, 1990
[PubMed]
 
Martins C, Gaffan EA: Effects of early maternal depression on patterns of infant-mother attachment: a meta-analytic investigation. J Child Psychol Psychiatry 41:737–746, 2000
[PubMed]
 
Maschi S, Clavenna A, Campi R, et al: Neonatal outcome following pregnancy exposure to antidepressants: a prospective controlled cohort study. BJOG 115:283–289, 2008
[PubMed]
 
Matalon S, Schechtman S, Goldzweig G, et al: The teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures. Reprod Toxicol 16:9–17, 2002
[PubMed]
 
Matheson I, Pande H, Alertson AR: Respiratory depression caused by N-desmethyldoxepine in breast milk. Lancet 2(8464): 1124, 1985
[PubMed]
 
Matheson I, Skjaeraasen J: Milk concentrations of flupenthixol, nortriptyline and zuclopenthixol and between breast differences in two patients. Eur J Clin Pharmacol 35:217–220, 1988
[PubMed]
 
Mattison DR: Physiologic variations in pharmacokinetics during pregnancy, in Drug and Chemical Action in Pregnancy: Pharmacologic and Toxicologic Principles. Edited by Fabro S, Scialli A. New York, Marcel Dekker, 1986, pp 37–102
 
Mattison DR, Blann E, Malek A: Physiological alterations during pregnancy: impact on toxicokinetics. Fundam Appl Toxicol 16:215–218, 1991
[PubMed]
 
Mazzi E: Possible neonatal diazepam withdrawal: a case report. Am J Obstet Gynecol 129:586–587, 1977
[PubMed]
 
McAuley DM, O'Neill MP, Moore J, et al: Lorazepam premedication for labour. Br J Obstet Gynecol 89:149–154, 1982
[PubMed]
 
McBride WG: Limb deformities associated with iminodibenzyl hydrochloride. Med J Aust 1:175–178, 1972
 
McCormick CM, Smythe JW, Sharma S, et al: Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats. Brain Res 84:55–61, 1995
[PubMed]
 
McElhatton PR, Garbis HM, Elefant E, et al: The outcome of pregnancy in 689 women exposed to therapeutic doses of antidepressants. A collaborative study of the European Network of Teratology Information Services (ENTIS). Reprod Toxicol 10:285–294, 1996
[PubMed]
 
McEvoy JP, Hatcher A, Appelbaum PS, et al: Chronic schizophrenic women's attitudes toward sex, pregnancy, birth control, and childrearing. Hosp Community Psychiatry 34:536–539, 1983
[PubMed]
 
McGorry P, Conell S: The nosology and prognosis of puerperal psychosis: a review. Compr Psychiatry 31:519–534, 1990
[PubMed]
 
McKenna K, Koren G, Tetelbaum M, et al: Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparison study. J Clin Psychiatry 66:444–449, 2005
[PubMed]
 
McMahon CL, Braddock SR: Septo-optic dysplasia as a manifestation of valproic acid embryopathy. Teratology 64:83–86, 2001
[PubMed]
 
McNeil TF, Kaij L, Malmquist-Larson A: Women with nonorganic psychosis: mental disturbance during pregnancy. Acta Psychiatr Scand 70:127–139, 1984a
 
McNeil TF, Kaij L, Malmquist-Larson A: Women with nonorganic psychosis: pregnancy's effect on mental health during pregnancy. Acta Psychiatr Scand 70:140–148, 1984b
 
Meador KJ, Baker GA, Finnell RH, et al: In utero antiepileptic drug exposure: fetal death and malformations. Neurology 67:407–412, 2006
[PubMed]
 
Meijer A: Child psychiatric sequelae of maternal war stress. Acta Psychiatr Scand 72:505–511, 1985
[PubMed]
 
Mendenhall HW: Serum protein concentrations in pregnancy, I: concentrations in maternal serum. Am J Obstet Gynecol 106:388–399, 1970
[PubMed]
 
Merlob P, Mor N, Litwin A: Transient hepatic dysfunction in an infant of an epileptic mother treated with carbamazepine during pregnancy and breastfeeding. Ann Pharmacother 26:1563–1565, 1992
[PubMed]
 
Metcalfe J, Romney SL, Ramsey LH, et al: Estimation of uterine blood flow in women at term. J Clin Invest 34:1632–1638, 1955
[PubMed]
 
Milkovich L, Van den Berg BJ: An evaluation of the teratogenicity of certain antinauseant drugs. Am J Obstet Gynecol 125:244–248, 1976
 
Miller LJ: Clinical strategies for the use of psychotropic drugs during pregnancy. Psychiatr Med 9:275–298, 1991
[PubMed]
 
Miller LJ: Use of electroconvulsive therapy during pregnancy. Hosp Community Psychiatry 45:444–450, 1994
[PubMed]
 
Miller LJ: Sexuality, reproduction, and family planning in women with schizophrenia. Schizophr Bull 23:623–635, 1997
[PubMed]
 
Miller LJ, Finnerty M: Sexuality, pregnancy, and childrearing among women with schizophrenia-spectrum disorders. Psychiatr Serv 47:502–506, 1996
[PubMed]
 
Misri S, Sivertz K: Tricyclic drugs in pregnancy and lactation: a preliminary report. Int J Psychiatry Med 21:157–171, 1991
[PubMed]
 
Misri S, Oberlander TF, Fairbrother N, et al: Relation between prenatal maternal mood and anxiety and neonatal health. Can J Psychiatry 49:684–689, 2004
[PubMed]
 
Mizrahi EM, Hobbs JF, Goldsmith DI: Nephrogenic diabetes insipidus in transplacental lithium intoxication. J Pediatr 94:493–495, 1979
[PubMed]
 
Moore SJ, Turnpenny P, Quinn A, et al: A clinical study of 57 children with fetal anticonvulsant syndromes. J Med Genet 37:489–497, 2000
[PubMed]
 
Moore WM, Hellegers AE, Battaglia FC: In vitro permeability of different layers of human placenta to carbohydrates and urea. Am J Obstet Gynecol 96:951–955, 1966
[PubMed]
 
Morgan DJ: Drug disposition in mother and foetus. Clin Exp Pharmacol Physiol 24:869–873, 1997
[PubMed]
 
Moriarty AJ, Nance NR: Trifluoperazine and pregnancy. Can Med Assoc J 88:375–376, 1963
 
Morrow J, Russell A, Guthrie E, et al: Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 77:193–198, 2006
[PubMed]
 
Moses-Kolko EL, Bogen D, Perel J, et al: Neonatal signs after late in utero exposure to serotonin reuptake inhibitors: literature review and implications for clinical applications. JAMA 293:2372–2383, 2005
[PubMed]
 
Mountain KR, Hirsh J, Gallus AS: Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy. Lancet 1(7641):265–268, 1970
[PubMed]
 
Myllynen PK, Pienimaki PK, Vahakangas KH: Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo. Eur J Clin Pharmacol 58:677–682, 2003
[PubMed]
 
Myslivecek J, Hassmannova J, Josifko M: Impact of prenatal low-dose diazepam or chlorpromazine on reflex and motor development and inhibitory-learning. Homeost Health Dis 33:77–88, 1991
[PubMed]
 
Nau H, Rating D, Koch S, et al: Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers. J Pharmacol Exp Ther 219:768–777, 1981
[PubMed]
 
Nau H, Kuhnz W, Egger HJ, et al: Anticonvulsants during pregnancy and lactation: transplacental, maternal and neonatal pharmacokinetics. Clin Pharmacokinet 7:508–543, 1982a
 
Nau H, Wittfoht W, Rating D, et al: Pharmacokinetics of valproic acid and its metabolites in a pregnant patient: stable isotope methodology, in Epilepsy, Pregnancy, and the Child. Edited by Janz D, Bossi L, Dam M, et al: New York, Raven Press, 1982b, pp 131–139
 
New York State Department of Health: Congenital Malformations Registry Summary Report: Statistical Summary of Children Born in 1998–2001 and Diagnosed Through 2003. Troy, NY, Congenital Malformations Registry, New York State Department of Health, 2005. Available at: http://www.health.state.ny.us/nysdoh/cmr/docs/98report.pdf. Accessed November 2007.
 
Newport DJ, Wilcox M, Stowe ZN: Antidepressants during pregnancy and lactation: defining exposure. Semin Perinatol 25:177–190, 2001
[PubMed]
 
Newport DJ, Hostetter A, Arnold A, et al: The treatment of postpartum depression: minimizing infant exposures. J Clin Psychiatry 63 (suppl 7):31–44, 2002a
 
Newport DJ, Stowe ZN, Nemeroff CB: Parental depression: animal models of an adverse life event. Am J Psychiatry 159:1265–1283, 2002b
 
Newport DJ, Owens MJ, Knight DL, et al: Alterations in platelet serotonin transporter binding in women with postpartum onset major depression. J Psychiatr Res 38:467–473, 2004
[PubMed]
 
Newport DJ, Viguera AC, Beach AJ, et al: Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy. Am J Psychiatry 162:2162–2170, 2005
[PubMed]
 
Newport DJ, Calamaras MR, DeVane CL, et al: Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. Am J Psychiatry 164:1214–1220, 2007
[PubMed]
 
Newport DJ, Pennell PB, Calamaras MR, et al: Lamotrigine in breast milk and nursing infants: determination of exposure. Pediatrics 122:e223–e231, 2008a
 
Newport DJ, Stowe ZN, Viguera AC, et al: Lamotrigine in bipolar disorder: efficacy during pregnancy. Bipolar Disord 10:432–436, 2008b
 
Neziroglu FN, Anemone MA, Yaryura-Tobias JA: Onset of obsessive-compulsive disorder in pregnancy. Am J Psychiatry 149:947–950, 1992
[PubMed]
 
Niebyl JR, Blake DA, Freeman JM, et al: Carbamazepine levels in pregnancy and lactation. Obstet Gynecol 53:139–140, 1979
[PubMed]
 
Nonacs R, Cohen LS: Depression during pregnancy: diagnosis and treatment options. J Clin Psychiatry 63 (suppl 7):24–30, 2002
 
Nora JJ, Nora AH, Toews WH: Letter: Lithium, Ebstein's anomaly, and other congenital heart defects. Lancet 2(7880):594–595, 1974
[PubMed]
 
Nulman I, Rovet J, Stewart DE, et al: Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 336:258–262, 1997a
 
Nulman I, Scolnick D, Chitayat D, et al: Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. Am J Med Genet 68:18–24, 1997b
 
Nulman I, Rovet J, Stewart DE, et al: Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study. Am J Psychiatry 159:1889–1895, 2002
[PubMed]
 
Nurnberg HG, Prudic J: Guidelines for treatment of psychosis during pregnancy. Hosp Community Psychiatry 35:67–71, 1984
[PubMed]
 
Oberlander TF, Misri S, Fitzgerald CE, et al: Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure. J Clin Psychiatry 65:230–237, 2004
[PubMed]
 
Oberlander TF, Warburton W, Misri S, et al: Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry 63:898–906, 2006
[PubMed]
 
Oberlander TF, Reebye P, Misri S, et al: Externalizing and attentional behaviors in children of depressed mothers treated with a selective serotonin reuptake inhibitor antidepressant during pregnancy. Arch Pediatr Adolesc Med 161:22–29, 2007
[PubMed]
 
O'Connor MO, Johnson GH, James DI: Intrauterine effect of phenothiazines. Med J Aust 1:416–417, 1981
[PubMed]
 
O'Connor TG, Heron J, Golding J, et al: Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis. J Child Psychol Psychiatry 44:1025–1036, 2003
[PubMed]
 
Oesterheld JR: A review of developmental aspects of cytochrome P450. J Child Adolesc Psychopharmacol 8:161–174, 1998
[PubMed]
 
O'Hara MW, Rehm LP, Campbell SB: Predicting depressive symptomatology: cognitive-behavioural models and postpartum depression. J Abnorm Psychol 91:457–461, 1982
[PubMed]
 
O'Hara MW, Stuart S, Gorman LL, et al: Efficacy of interpersonal psychotherapy for postpartum depression. Arch Gen Psychiatry 57:1039–1045, 2000
[PubMed]
 
Ohman I, Vitols S, Tomson T: Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 41:709–713, 2000
[PubMed]
 
Ohman R, Hagg S, Carleborg L, et al: Excretion of paroxetine into breast milk. J Clin Psychiatry 60:519–523, 1999
[PubMed]
 
Omtzigt JG, Nau H, Los FJ, et al: The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida. Eur J Clin Pharmacol 43:381–388, 1992
[PubMed]
 
Omtzigt JG, Los FJ, Meijer JW, et al: The 10,11-epoxide-10, 11-diol pathway of carbamazepine in early pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, comedication, and relation to outcome of pregnancy. Ther Drug Monit 15:1–10, 1993
[PubMed]
 
Oo CY, Kuhn RJ, Desai N, et al: Active transport of cimetidine into human milk. Clin Pharmacol Ther 58:548–555, 1995
[PubMed]
 
Ordy JM, Samorajski T, Collins RL: Prenatal chlorpromazine effects on liver survival and behavior of mice offspring. J Pharmacol Exp Ther 151:110–125, 1966
[PubMed]
 
Ornoy A, Cohen E: Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy. Arch Dis Child 75:517–520, 1996
[PubMed]
 
Orr S, Miller C: Maternal depressive symptoms and the risk of poor pregnancy outcome. Epidemiol Rev 17:165–170, 1995
[PubMed]
 
Orr ST, James SA, Blackmore Prince C: Maternal prenatal depressive symptoms and spontaneous preterm births among African-American women in Baltimore, Maryland. Am J Epidemiol 156:797–802, 2002
[PubMed]
 
Otani K: Risk factors for the increased seizure frequency during pregnancy and puerperium. Folia Psychiatr Neurol Jpn 39:33–41, 1985
[PubMed]
 
Owens M, Hostetter AL, Knight DL, et al: Fetal exposure to SERT antagonist antidepressants in rats. Presented at the annual meeting of the Society for Neuroscience, New Orleans, LA, October 25–30, 1997
 
Pacifici GM, Nottoli R: Placental transfer of drugs administered to the mother. Clin Pharmacokinet 28:235–269, 1995
[PubMed]
 
Page-Sharp M, Kristensen JH, Hackett LP, et al: Transfer of lamotrigine into breast milk. Ann Pharmacother 40:1470–1471, 2006
[PubMed]
 
Parkin DE: Probable Benadryl withdrawal manifestations in a newborn infant. J Pediatr 85:580, 1974
[PubMed]
 
Parry BL, Javeed S, Laughlin GA, et al: Cortisol circadian rhythms during the menstrual cycle and with sleep deprivation in premenstrual dysphoric disorder and normal control subjects. Biol Psychiatry 48:920–931, 2000
[PubMed]
 
Parry E, Shields R, Turnbull AC: Transit time in the small intestine in pregnancy. Br J Obstet Gynaecol 77:900–901, 1970
[PubMed]
 
Pastuszak A, Schick-Boschetto B, Zuber C, et al: Pregnancy outcome following first trimester exposure to fluoxetine (Prozac). JAMA 269:2246–2248, 1993
[PubMed]
 
Pauk J, Kuhn C, Field T, et al: Positive effects of tactile versus kinesthetic or vestibular stimulation on neuroendocrine and ODC activity in maternally deprived rat pups. Life Sci 39:2081–2087, 1986
[PubMed]
 
Paulson GW, Paulson RB: Teratogenic effects of anticonvulsants. Arch Neurol 38:140–143, 1981
[PubMed]
 
Pedersen CA, Stern RA, Pate J, et al: Thyroid and adrenal measures during late pregnancy and the puerperium in women who have been major depressed or who become dysphoric postpartum. J Affect Disord 29:201–211, 1993
[PubMed]
 
Pennell P, Gleba J, Clements S: Antiepileptic drug monitoring during pregnancy in women with epilepsy. Epilepsia 41:200, 2000
 
Pennell PB, Newport DJ, Stowe ZN, et al: The impact of pregnancy and childbirth on the metabolism of lamotrigine. Neurology 62:292–295, 2004
[PubMed]
 
Pennell PB, Peng L, Newport DJ, et al: Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology 70(22 pt 2):2130–2136, 2008
 
Perkin R, Bland J, Peacock J, et al: The effect of anxiety and depression during pregnancy on obstetric complications. Br J Obstet Gynaecol 100:629–634, 1993
[PubMed]
 
Perucca E, Crema A: Plasma protein binding of drugs in pregnancy. Clin Pharmacokinet 7:336–352, 1982
[PubMed]
 
Peters D: Prenatal stress: effects on brain biogenic amine and plasma corticosterone levels. Pharmacol Biochem Behav 17:721–725, 1982
[PubMed]
 
Peters D: Prenatal stress: Effect on development of rat brain adrenergic receptors. Pharmacol Biochem Behav 21:417–422, 1984
[PubMed]
 
Peters D: Prenatal stress increases the behavioral response to serotonin agonists and alters open field behavior in the rat. Pharmacol Biochem Behav 25:873–877, 1986
[PubMed]
 
Peters D: Effects of maternal stress during different gestational periods on the serotonergic system in adult rat offspring. Pharmacol Biochem Behav 31:839–843, 1988
[PubMed]
 
Peters D: Maternal stress increases fetal brain and neonatal cerebral cortex 5-hydroxytryptamine synthesis in rats: a possible mechanism by which stress influences brain development. Pharmacol Biochem Behav 35:943–947, 1990
[PubMed]
 
Petersen VP: Body composition and fluid compartments in normal, obese and underweight human subjects. Acta Med Scand 108:103–111, 1957
 
Peto R, Baigent C: Trials: the next 50 years. BMJ 317:1170–1171, 1998
[PubMed]
 
Petrenaite V, Sabers A, Hansen-Schwartz J. Individual changes in lamotrigine plasma concentrations during pregnancy. Epilepsy Research 65:185–188, 2005
[PubMed]
 
Pfister H, Muir J: Prenatal exposure to predictable and unpredictable novelty stress and oxytocin treatment affects offspring development and behavior in rats. Int J Neurosci 62:227–241, 1992
[PubMed]
 
Philbert A, Pederson B, Dam M: Concentration of valproate during pregnancy in the newborn and in breast milk. Acta Neurol Scand 72:460–463, 1985
[PubMed]
 
Physicians' Desk Reference (PDR), 61st Edition. Montvale, NJ, Thomson Healthcare, 2007
 
Pihoker C, Owens M, Kuhn C, et al: Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor. Psychoneuroendocrinology 7:485–493, 1993
 
Piontek CM, Baab S, Peindl KS, et al: Serum valproate levels in 6 breast-feeding mother-infant pairs. J Clin Psychiatry 61:170–172, 2000
[PubMed]
 
Piontek CM, Wisner KL, Perel JM, et al: Serum fluvoxamine levels in breastfed infants. J Clin Psychiatry 52:111–113, 2001
 
Pittard WB, O'Neal W: Amitriptyline excretion in human milk. J Clin Psychopharmacol 6:383–384, 1986
[PubMed]
 
Plentl AA, Gray MJ: Total body water, sodium space and total exchangeable sodium in normal and toxemic pregnant women. Am J Obstet Gynecol 78:472–478, 1959
[PubMed]
 
Poltyrev T, Keshet G, Kay G, et al: Role of experimental conditions in determining differences in exploratory behavior of prenatally stressed rats. Dev Psychobiol 29:453–462, 1996
[PubMed]
 
Poulson E, Robson JM: Effect of phenelzine and some related compounds in pregnancy. J Endocrinol 30:205–215, 1964
[PubMed]
 
Prentice A, Brown R: Fetal tachyarrhythmia and maternal antidepressant treatment. BMJ 298:190, 1989
[PubMed]
 
Pynnonen S, Sillanpaa M: Letter: carbamazepine and mother's milk. Lancet 2(7934):563, 1975
[PubMed]
 
Pynnonen S, Kanto J, Sillanpaa M, et al: Carbamazepine: placental transport, tissue concentrations in foetus and newborn, and level in milk. Acta Pharmacol Toxicol 41:244–253, 1977
[PubMed]
 
Rambeck B, Kurlemann G, Stodieck SR, et al: Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child. Eur J Clin Pharmacol 51:481–484, 1997
[PubMed]
 
Rampono J, Hackett LP, Kristensen JH, et al: Transfer of escitalopram and its metabolite desmethylescitalopram into breastmilk. Br J Clin Pharmacol 62:316–322, 2006
[PubMed]
 
Rawlings WJ, Ferguson R, Maddison TG: Phenmetrazine and trifluoperazine. Med J Aust 1:370, 1963
 
Rieder RO, Rosenthal D, Wender P, et al: The offspring of schizophrenics: fetal and neonatal deaths. Arch Gen Psychiatry 32:200–211, 1975
[PubMed]
 
Rimm AA, Katayama AC, Diaz M, et al: A meta-analysis of controlled studies comparing major malformation rates in IVF and ICSI infants with naturally conceived children. J Assist Reprod Genet 21:437–443, 2004
[PubMed]
 
Riordan D, Appleby L, Faragher B: Mother-infant interaction in post-partum women with schizophrenia and affective disorders. Psychol Med 29:991–995, 1999
[PubMed]
 
Robertson RT, Majka JA, Peter CP, et al: Effects of prenatal exposure to chlorpromazine on postnatal development and behavior of rats. Toxicol Appl Pharmacol 53:541–549, 1980
[PubMed]
 
Robson SC, Mutch E, Boy RJ, et al: Apparent liver blood flow during pregnancy: a serial study using indicyanine green clearance. Br J Obstet Gynaecol 97:720–724, 1990
[PubMed]
 
Rodriguez-Pinilla E, Arroyo I, Fondevilla J, et al: Prenatal exposure to valproic acid during pregnancy and limb deficiencies: a case-control study. Am J Med Genet 90:376–381, 2000
[PubMed]
 
Rosa FW: Spina bifida in infants of women treated with carbamazepine during pregnancy. N Engl J Med 324:674–677, 1991
[PubMed]
 
Rosenberg L, Mitchell AA, Parsells JL, et al: Lack of relation of oral clefts to diazepam use during pregnancy. N Engl J Med 309:1281–1285, 1984
 
Rosenblum L, Paully G: The effects of varying environmental demands on maternal and infant behavior. Child Dev 55:305–314, 1984
[PubMed]
 
Rumeau-Rouquette C, Goujard J, Huel G: Possible teratogenic effect of phenothiazines in human beings. Teratology 15:57–64, 1977
[PubMed]
 
Rybakowski JK: Moclobemide in pregnancy. Pharmacopsychiatry 34:82–83, 2001
[PubMed]
 
Sabers A, Dam M, A-Rogvi-Hansen B, et al: Epilepsy and pregnancy: lamotrigine as main drug used. Acta Neurol Scand 109:9–13, 2004
[PubMed]
 
Sadler TW (ed): Langman's Medical Embryology, 5th Edition. Baltimore, MD, Williams & Wilkins, 1985, pp 58–88
 
Samrén E, van Duijn C, Koch S, et al: Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy. Epilepsia 38:981–990, 1997
[PubMed]
 
Samrén E, van Duijn C, Christiaens G, et al: Antiepileptic drug regimens and major congenital abnormalities in the offspring. Ann Neurol 46:739–746, 1999
[PubMed]
 
Sanchis A, Rosique D, Catala J: Adverse effects of maternal lorazepam on neonates. Ann Pharmacother 25:1137–1138, 1991
[PubMed]
 
Sathanandar S, Blesi K, Tran T, et al: Lamotrigine clearance increases markedly during pregnancy. Epilepsia 41:246, 2000
 
Saxén I: Cleft palate and maternal diphenhydramine intake. Lancet 1(7854):407–408, 1974
[PubMed]
 
Saxén I: Association between oral clefts and drugs taken during pregnancy. Int J Epidemiol 4:37–44, 1975
[PubMed]
 
Saxén I, Saxén L: Association between maternal intake of diazepam and oral clefts. Lancet 2(7933):498, 1974
[PubMed]
 
Schatzberg AF, Cole JO: Manual of Clinical Psychopharmacology, 2nd Edition. Washington, DC, American Psychiatric Press, 1991
 
Schell L: Environmental noise and human prenatal growth. Am J Physiol Anthropol 56:63–70, 1981
[PubMed]
 
Schick-Boschetto B, Zuber C: Alprazolam exposure during early human pregnancy. Teratology 45:460, 1992
 
Schmidt K, Olesen O, Jensen P: Citalopram and breast-feeding: serum concentration and side effects in the infant. Biol Psychiatry 47:164–165, 2000
[PubMed]
 
Schneider M: Prenatal stress exposure alters postnatal behavioral expression under conditions of novelty challenge in rhesus monkey infants. Dev Psychobiol 25:529–540, 1992
[PubMed]
 
Schneider M, Roughton E, Koehler A, et al: Growth and development following prenatal stress exposure in primates: an examination of ontogenetic vulnerability. Child Dev 70:263–274, 1999
[PubMed]
 
Schou M: What happened later to the lithium babies?: follow-up study of children born without malformations. Acta Psychiatr Scand 54:193–197, 1976
[PubMed]
 
Schou M, Amdisen A: Lithium and pregnancy, III: lithium ingestion by children breast-fed by women on lithium treatment. BMJ 2:138, 1973
[PubMed]
 
Scokel PW, Jones WD: Infant jaundice after phenothiazine drugs for labor: an enigma. Obstet Gynecol 20:124–127, 1962
[PubMed]
 
Scolnick D, Nulman I, Rovet J, et al: Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. JAMA 271:767–770, 1994
 
Secoli S, Teixeira N: Chronic prenatal stress affects development and behavioral depression in rats. Stress 2:273–280, 1998
[PubMed]
 
Shannon RW, Fraser GP, Aitken RG, et al: Diazepam in preeclamptic toxaemia with special reference to its effect on the newborn infant. Br J Clin Pract 26:271–275, 1972
[PubMed]
 
Shiono PH, Mills JL: Oral clefts and diazepam use during pregnancy. N Engl J Med 311:919–920, 1984
[PubMed]
 
Simon GE, Cunningham ML, Davis RL: Outcomes of prenatal antidepressant exposure. Am J Psychiatry 159:2055–2061, 2002
[PubMed]
 
Sivojelezova A, Shuhaiber S, Sarkissian L, et al: Citalopram use in pregnancy: prospective comparative evaluation of pregnancy and fetal outcome. Am J Obstet Gynecol 193:2004–2009, 2005
[PubMed]
 
Skausig OB, Schou M: Breast feeding during lithium therapy [Danish]. Ugeskrift for Laeger 139:400–401, 1977
[PubMed]
 
Slayton RI, Soloff PH: Psychotic denial of third-trimester pregnancy. J Clin Psychiatry 42:471–473, 1981
[PubMed]
 
Slone D, Siskind V, Heinonen OP, et al: Antenatal exposure to the phenothiazines in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. Am J Obstet Gynecol 128:468–486, 1977
 
Smith B, Wills G, Naylor D: The effects of prenatal stress on rat offsprings' learning ability. J Psychol 107:45–51, 1981
[PubMed]
 
Sodhi P, Poddar B, Parmar V: Fatal cardiac malformation in fetal valproate syndrome. Indian J Pediatr 68:989–990, 2001
[PubMed]
 
Speight AN: Floppy-infant syndrome and maternal diazepam and/or nitrazepam. Lancet 2(8043):878, 1977
[PubMed]
 
Spigset O, Carleborg L, Norstrom A, et al: Paroxetine level in breast milk. J Clin Psychiatry 57:39, 1996
[PubMed]
 
Spigset O, Carleborg L, Ohman R, et al: Excretion of citalopram in breast milk. Br J Clin Pharmacol 44:295–298, 1997
[PubMed]
 
Spinelli MG: Interpersonal psychotherapy for depressed antepartum women: a pilot study. Am J Psychiatry 154:1028–1030, 1997
[PubMed]
 
St. Clair SM, Schirmer RG: First trimester exposure to alprazolam. Obstet Gynecol 80:843–846, 1992
 
Stahl MM, Neiderud J, Vinge E: Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid. J Pediatr 130:1001–1003, 1997
[PubMed]
 
Stancer HC, Reed KL: Desipramine and 2-hydroxydesipramine in human breast milk and the nursing infant's serum. Am J Psychiatry 143:1597–1600, 1986
[PubMed]
 
Steer R, Scholl T, Hediger M, et al: Self-reported depression and negative pregnancy outcomes. Epidemiology 45:1093–1099, 1992
[PubMed]
 
Stewart R, Karas B, Springer P: Haloperidol excretion in human milk. Am J Psychiatry 137:849–850, 1980
[PubMed]
 
Stirrat GM, Edington P, Berry DJ: Transplacental passage of chlordiazepoxide. BMJ 2:729, 1974
[PubMed]
 
Stoner SC, Sommi RW, Marken PA, et al: Clozapine use in two full-term pregnancies. J Clin Psychiatry 58:364–365, 1997
[PubMed]
 
Stott D: Follow-up study from birth of the effects of prenatal stresses. Dev Med Child Neurol 15:770–787, 1973
[PubMed]
 
Stowe ZN, Nemeroff CB: Women at risk for postpartum-onset major depression. Am J Obstet Gynecol 173:639–645, 1995
[PubMed]
 
Stowe ZN, Owens MJ, Landry JC, et al: Sertraline and desmethylsertraline in human breast milk and nursing infants. Am J Psychiatry 154:1255–1260, 1997
[PubMed]
 
Stowe ZN, Cohen LS, Hostetter A, et al: Paroxetine in breast milk and nursing infants. Am J Psychiatry 157:185–189, 2000
[PubMed]
 
Stowe ZN, Calhoun K, Ramsey C, et al: Mood disorders during pregnancy and lactation: defining exposure and treatment issues. CNS Spectr 6:150–166, 2001
 
Stowe Z, Hostetter A, Newport D: The onset of postpartum depression: implications for clinical screening in obstetrical and primary care. Am J Obstet Gynecol 192:522–526, 2005
[PubMed]
 
Sullivan FM, McElhatton PR: A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and pyrimidone in mice. Toxicol Appl Pharmacol 40:365–378, 1977
[PubMed]
 
Summerfield RJ, Nielsen MS: Excretion of lorazepam into breast milk. Br J Anaesth 57:1042–1043, 1985
[PubMed]
 
Suri R, Stowe ZN, Hendrick V, et al: Estimates of nursing infant daily dose of fluoxetine through breast milk. Biol Psychiatry 52:446–451, 2002
[PubMed]
 
Swedish Centre for Epidemiology: Registration of congenital malformations in the Swedish Health Registers. Stockholm, Sweden, National Board of Health and Welfare, Centre for Epidemiology, June 18, 2004. Available at: http://www.socialstyrelsen.se/Publicerat/2004/5120/2004-112-1.htm. Accessed December 2007
 
Sykes PA, Quarrie J, Alexander FW: Lithium carbonate and breast-feeding. BMJ 2:1299, 1976
[PubMed]
 
Szuran T, Zimmerman E, Pliska V, et al: Prenatal stress effects on exploratory activity and stress-induced analgesia in rats. Dev Psychobiol 24:361–372, 1991
[PubMed]
 
Taddio A, Ito S, Koren G: Excretion of fluoxetine and its metabolite norfluoxetine in human breast milk. J Clin Pharmacol 36:42–47, 1996
[PubMed]
 
Takahashi LK: Prenatal stress: consequences of glucocorticoids on hippocampal development and function. Int J Dev Neurosci 16:199–207, 1998
[PubMed]
 
Takahashi L, Kalin N: Early developmental and temporal characteristics of stress-induced secretion of pituitary-adrenal hormones in prenatally stress rat pups. Brain Res 558:75–78, 1991
[PubMed]
 
Targum S, Davenport Y, Webster M: Postpartum mania in bipolar manic-depressive patients withdrawn from lithium carbonate. J Nerv Ment Dis 167:572–574, 1979
[PubMed]
 
Tenyi T, Tixler M: Clozapine in the treatment of pregnant schizophrenic women. Psychiatria Danubina 10:15–18, 1998
 
Thisted E, Ebbesen F: Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero. Arch Dis Child 69:288–291, 1993
[PubMed]
 
Toddywalla VS, Kari FW, Neville MC: Active transport of nitrofurantoin across a mouse mammillary epithelial monolayer. J Pharmacol Exp Ther 280:669–676, 1997
[PubMed]
 
Tomson T, Lindborn U, Ekqvist B, et al: Disposition of carbamazepine and phenytoin in pregnancy. Epilepsia 35:131–135, 1994
[PubMed]
 
Tomson T, Ohman I, Vitols S: Lamotrigine in pregnancy and lactation: a case report. Epilepsia 38:1039–1041, 1997
[PubMed]
 
Tran TA, Leppik IE, Blesi K, et al: Lamotrigine clearance during pregnancy. Neurology 59:251–255, 2002
[PubMed]
 
Troutman B, Cutrona C: Nonpsychotic postpartum depression among adolescent mothers. J Abnorm Psychol 99:69, 1990
[PubMed]
 
Tsuru N, Maeda T, Tsuruoka M: Three cases of delivery under sodium valproate—placental transfer, milk transfer and probable teratogenicity of sodium valproate. Jpn J Psychiatry Neurol 42:89–96, 1988
[PubMed]
 
Tsutsumi K, Kotegawa T, Matsuki S, et al: The effect of pregnancy on cytochrome P450 1A2, xanthine oxidase, and N-acetyltransferase activities in humans. Clin Pharmacol Ther 70:121–125, 2001
[PubMed]
 
Tunnessen WW, Hertz CG: Toxic effects of lithium in newborn infants: a commentary. J Pediatr 81:804–807, 1972
[PubMed]
 
U.S. Food and Drug Administration: FDA advising of risk of birth defects with Paxil: agency requiring updated product labeling. FDA News P05–P97, 2005
 
Vail A, Hornbuckle J, Spiegelhalter DJ, et al: Prospective application of Bayesian monitoring and analysis in an open randomized clinical trial. Stat Med 20:3777–3787, 2001
[PubMed]
 
Vajda FJ, O'Brien TJ, Hitchcock A, et al: The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months. J Clin Neurosci 10:543–549, 2003
[PubMed]
 
Vallee M, Mayo W, Dellu F, et al: Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: correlation with stress-induced corticosterone secretion. J Neuroscience 17:2626–2636, 1997
[PubMed]
 
Van der Pol MC, Hadders-Algra M, Huisjes MJ, et al: Antiepileptic medication in pregnancy: late effects on the children's nervous system development. Am J Obstet Gynecol 164:121–128, 1991
 
Van Waes A, Van de Velde EJ: Safety evaluation of haloperidol in the treatment of hyperemesis gravidarum. J Clin Pharmacol 9:224–227, 1969
 
Viguera AC, Nonacs R, Cohen LS, et al: Risk of recurrence of bipolar disorder in pregnant and nonpregnant women after discontinuing lithium maintenance. Am J Psychiatry 157:179–184, 2000
[PubMed]
 
Viguera AC, Whitfield T, Baldessarini RJ, et al: Risk of recurrence in women with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuation. Am J Psychiatry 164:1817–1824, 2007
[PubMed]
 
von Unruh GE, Froescher W, Hoffmann F, et al: Valproic acid in breast milk: how much is really there? Ther Drug Monit 6:272–276, 1984
 
Wadelius M, Darj E, Frenne G, et al: Induction of CYP2D6 in pregnancy. Clin Pharmacol Ther 62:400–407, 1997
[PubMed]
 
Wadhwa PD, Porto M, Garite TJ, et al: Maternal corticotropin-releasing hormone levels in the early third trimester predict length of gestation in human pregnancy. Am J Obstet Gynecol 179:1079–1085, 1998
[PubMed]
 
Wakshlak A, Weinstock M: Neonatal handling reverses behavioral abnormalities induced in rats by prenatal stress. Physiol Behav 48:289–292, 1990
[PubMed]
 
Waldman MD, Safferman AZ: Pregnancy and clozapine. Am J Psychiatry 150:168–169, 1993
[PubMed]
 
Walker C, Scribner K, Cascio C, et al: The pituitary-adrenocortical system of neonatal rats is responsive to stress throughout development in a time-dependent and stressor-specific fashion. Endocrinology 128:1385–1395, 1991
[PubMed]
 
Wang JS, Newport DJ, Stowe ZN, et al: The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient. Drug Metabolism Reviews 39:723–746, 2007
[PubMed]
 
Warner A: Drug use in the neonate: inter-relationships of pharmacokinetics, toxicity and biochemical maturity. Clin Chem 32:721–727, 1986
[PubMed]
 
Watson JP, Elliott SA, Rugg AJ, et al: Psychiatric disorder in pregnancy and the first postnatal year. Br J Psychiatry 144:453–462, 1984
[PubMed]
 
Webster PA: Withdrawal symptoms in neonates associated with maternal antidepressant therapy. Lancet 2(7824):318–319, 1973
[PubMed]
 
Weinstein MR, Goldfield M: Lithium carbonate treatment during pregnancy; report of a case. Dis Nerv System 30:828–832, 1969
[PubMed]
 
Weinstein MR, Goldfield MD: Cardiovascular malformations with lithium use during pregnancy. Am J Psychiatry 132:529–531, 1975
[PubMed]
 
Weinstock M, Fride E, Hertzberg R: Prenatal stress effects on functional development of the offspring. Prog Brain Res 73:319–331, 1988
[PubMed]
 
Weinstock M, Matlina E, Maor G, et al: Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary-adrenal system in female rats. Brain Res 595:195–198, 1992
[PubMed]
 
Weissman MM, Prusoff BA, Gammon GD, et al: Psychopathology in the children (ages 6–18) of depressed and normal parents. J Am Acad Child Adolesc Psychiatry 23:78–84, 1984
[PubMed]
 
Welch R, Findlay J: Excretion of drugs in human breast milk. Drug Metab Rev 12:261–277, 1981
[PubMed]
 
Weller A, Glaubman H, Yehuda S, et al: Acute and repeated gestational stress affect offspring learning and activity in rats. Physiol Behavior 43:139–143, 1988
[PubMed]
 
Wesson DR, Camber S, Harkey M, et al: Diazepam and desmethyldiazepam in breast milk. J Psychoactive Drugs 17:55–56, 1985
[PubMed]
 
Whalley LJ, Blain PG, Prime JK: Haloperidol secreted in breast milk. BMJ 282:1746–1747, 1981
[PubMed]
 
Whitelaw AGL, Cummings AJ, McFadyen IR: Effect of maternal lorazepam on the neonate. BMJ 282:1106–1108, 1981
[PubMed]
 
Wide K, Winbladh B, Tomson BWT, et al: Psychomotor development and minor anomalies in children exposed to antiepileptic drugs in utero: a prospective population based study. Dev Med Child Neurol 42:87–92, 2000
[PubMed]
 
Williams G, King J, Cunningham M, et al: Fetal valproate syndrome and autism: additional evidence of an association. Dev Med Child Neurol 43:202–206, 2001
[PubMed]
 
Williams KE, Koran L: Obsessive-compulsive disorder in pregnancy, the puerperium, and the premenstruum. J Clin Psychiatry 58:330–334, 1997
[PubMed]
 
Williams PG, Hersh JH: A male with fetal valproate syndrome and autism. Dev Med Child Neurol 39:632–634, 1997
[PubMed]
 
Wilson JT, Brown RD, Cherek DR, et al: Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet 5:1–66, 1980
[PubMed]
 
Wilson N, Forfar JC, Godman MJ: Atrial flutter in the newborn resulting from maternal lithium ingestion. Arch Dis Child 58:538–549, 1983
[PubMed]
 
Wilton LV, Pearce GL, Martin RM, et al: The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England. Br J Obstet Gynaecol 105:882–889, 1998
[PubMed]
 
Winter RM: In utero exposure to benzodiazepines. Lancet 1(8533):627, 1987
 
Winter RM, Donnai D, Burn J, et al: Fetal valproate syndrome: is there a recognizable phenotype? J Med Genet 24:692–695, 1987
[PubMed]
 
Wisner KL, Perel JM: Psychopharmacologic agents and electroconvulsive therapy during pregnancy and the puerperium, in Psychiatric Consultation in Childbirth Settings: Parent- and Child-Oriented Approaches. Edited by Cohen RL. New York, Plenum, 1988, pp 165–206
 
Wisner KL, Perel JM: Serum levels of valproate and carbamazepine in breastfeeding mother-infant pairs. J Clin Psychopharmacol 18:167–169, 1998
[PubMed]
 
Wisner KL, Perel JM, Wheeler SB: Tricyclic dose requirements across pregnancy. Am J Psychiatry 150:1541–1542, 1993
[PubMed]
 
Wisner KL, Peindl KS, Hanusa BH: Effect of childbearing on the natural history of panic disorder with comorbid mood disorder. J Affect Disord 41:173–180, 1996a
 
Wisner KL, Perel JM, Findling RL: Antidepressant treatment during breast-feeding. Am J Psychiatry 153:1132–1137, 1996b
 
Wisner K, Perel J, Blumer J: Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs. Am J Psychiatry 155:690–692, 1998
[PubMed]
 
Wood M, Wood AJJ: Changes in plasma drug binding and alpha-1-acid glycoprotein in mother and newborn infant. Clin Pharmacol Ther 29:522–526, 1981
[PubMed]
 
Woods DL, Malan AF: Side effects of maternal diazepam on the newborn infant. S Afr Med J 54:636, 1978
[PubMed]
 
Woody JN, London WL, Wilbanks GD: Lithium toxicity in a newborn. Pediatrics 47:94–96, 1971
[PubMed]
 
Wreitland MA: Excretion of oxazepam in breast milk. Eur J Clin Pharmacol 33:209–210, 1987
 
Wright S, Dawling S, Ashford J: Excretion of fluvoxamine in breast milk. Br J Clin Pharmacol 31:209, 1991
[PubMed]
 
Wyska E, Jusko WJ: Approaches to pharmacokinetic/pharmacodynamic modeling during pregnancy. Semin Perinatol 25:124–132, 2001
[PubMed]
 
Yerby MS, Friel PN, Miller DQ: Carbamazepine protein binding and disposition in pregnancy. Ther Drug Monit 7:269–273, 1985
[PubMed]
 
Yerby MS, Friel PN, McCormick K, et al: Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding. Epilepsy Res 5:223–228, 1990
[PubMed]
 
Yerby MS, Friel PN, McCormick K: Antiepileptic drug disposition during pregnancy. Neurology 42:12–16, 1992
[PubMed]
 
Yoldas Z, Iscan A, Yoldas T, et al: A woman who did her own cesarean section. Lancet 348:135, 1996
[PubMed]
 
Yoshida K, Smith B, Craggs M, et al: Fluoxetine in breast-milk and developmental outcome of breast-fed infants. Br J Psychiatry 172:175–178, 1998a
 
Yoshida K, Smith B, Craggs M, et al: Neuroleptic drugs in breast-milk: a study of pharmacokinetics and of possible adverse effects in breast-fed infants. Psychol Med 28:81–91, 1998b
 
Zeskind PS, Stephens LE: Maternal selective serotonin reuptake inhibitor use during pregnancy and newborn neurobehavior. Pediatrics 113:368–375, 2004
[PubMed]
 
Zuckerman B, Amaro H, Bauchner H, et al: Depressive symptoms during pregnancy: relationship to poor health behaviors. Am J Obstet Gynecol 160:1107–1111, 1989
[PubMed]
 
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CME Activity

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Sample questions:
1.
Which of the following statements concerning the prevalence of psychiatric disorders during pregnancy is true?
2.
Untreated maternal depression during pregnancy increases obstetrical risks for the mother and child and may result in adverse effects for the newborn. Which of the following outcomes has been reported in pregnant mothers with depression?
3.
Which of the following pharmacokinetic changes occurs during pregnancy?
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
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Preconception maternal nutrition: a multi-site randomized controlled trial. BMC Pregnancy Childbirth 2014;14(1):111.doi:10.1186/1471-2393-14-111.
 
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