Neuropathology: Introduction | Classification of Traumatic Brain Injury | Pathology Associated With Fatal Head Injury | Pediatric Head Injury | Long-Term Sequelae of Brain Injury | Experimental Models | Key Clinical Points | Recommended Readings | References
Traumatic brain injury (TBI) remains a major cause
of morbidity and mortality throughout the world, affecting young
and old alike. Pathological data have been developed through observations
of human autopsies and developing animal models to investigate its mechanisms.
One always has to be aware of the limitations of both these approaches:
autopsies, in most cases, provide information relating to the most
severe end of the clinical spectrum of TBI, fatal outcome; animal
models do not represent the polypathology of human brain injury;
and there are likely to be significant differences in the anatomical
basis of injury and cellular responses between species.