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February 01, 2013
AJP CME Course for February 2013: Common Genetic Variation and Antidepressant Efficacy in Major Depressive Disorder: A Meta-Analysis of Three Genome-Wide Pharmacogenetic Studies
Expires January 31, 2015
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Self-Assessment Quiz

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1.
This study sought to identify single nucleotide polymorphisms (SNPs) that could predict treatment outcome. No individual associations were found, but polygenic scores were constructed that could explain between 0.5 and 1.2% of variance in outcome. These scores included how many independent markers?
2.
For the participants in the study who were treated with citalopram or escitalopram, which of the following outcome measures was strongly associated with SNPs in an intergenic region on chromosome 5?
3.
Which of the following is a limitation relating to the treatment studies that may have affected this meta-analysis?