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Deep Brain Stimulation for OCD and Major Depression

To the Editor: Deep brain stimulation has been proposed to alleviate treatment-resistant obsessive-compulsive disorder (OCD) (1). We examined the long-term efficacy of deep brain stimulation of the ventral caudate nucleus in a case of primary, severe, and intractable OCD with concomitant major depression.

We previously reported the case of Mr. A, a 56-year-old man suffering from a severely disabling and refractory form of OCD that began over 4 decades before (2). He mainly experienced somatic obsessions concerning potential disturbances in bodily functioning, especially regarding his arms, fingers, legs, and gastrointestinal tract, and his mental capacities, with compulsive verification of functioning, comprising repetitive voluntary movements, controlled intake of foods according to their purgative properties, and repeated mental acts of questioning. Aggressive obsessions with fear of embarrassing thoughts about his children occurred, although considerably less frequently. OCD coexisted only with a lifetime history of recurrent major depression. Mr. A’s written informed consent had been obtained before his participation in the study. Psychiatric assessments included the Yale-Brown Obsessive Compulsive Scale, the Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, and the Global Assessment of Functioning (GAF) scale. Neuropsychological assessments consisted of a wide range of tests primarily exploring memory and executive functions (2). These evaluations were performed independently and blindly, regarding stimulation settings. No pharmacological and/or psychological treatment was administered postoperatively.

We previously reported that deep brain stimulation of the ventral caudate nucleus progressively improved Mr. A’s depressive and anxiety symptoms until remission was achieved at 6 months (Hamilton depression scale score 7 and Hamilton anxiety scale score 10) (2). There was also a marked but delayed reduction in OCD symptom severity on the Yale-Brown Obsessive Compulsive Scale from a baseline score of 25 to 10 and 14 at 12 and 15 months after deep brain stimulation, respectively. His level of functioning on the GAF scale gradually increased from 35 to 60 over the first 15 months of the postoperative period (2). Failure of the pulse generator battery, which was discovered after a clinical impairment, did not affect depressive and anxiety symptom intensity but worsened his obsessive-compulsive manifestations, especially his somatic preoccupations and the related checking compulsions (Yale-Brown Obsessive Compulsive Scale score=21), with a slight deterioration of global functioning (GAF scale score=55) at 18 months. A return to remission levels of OCD (Yale-Brown Obsessive Compulsive Scale score <16) was observed 3 months after replacement of the generator and remained stable until the end of the 27-month follow-up (final Yale-Brown Obsessive Compulsive Scale score=12). This was paralleled by an improvement in psychosocial functioning (final GAF scale score=65). Of interest, no neuropsychological alteration or any adverse clinical effect was reported.

Thus, this finding strengthens our previous report, suggesting that deep brain stimulation of the ventral caudate nucleus could be a promising strategy for the treatment of refractory cases of both OCD and major depression.

References

1. Nuttin B, Cosyns P, Demeulemeester H, Gybels J, Meyerson B: Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder (letter). Lancet 1999; 354:1526[Medline]
2. Aouizerate B, Cuny E, Martin-Guehl C, Guehl D, Amieva H, Benazzouz A, Fabrigoule C, Allard M, Rougier A, Bioulac B, Tignol J, Burbaud P: Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression: case report. J Neurosurg 2004; 101:682–686[Medline]

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Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by AOUIZERATE, B. Articles by BURBAUD, P. Search for Related Content PubMed Citation Articles by AOUIZERATE, B. Articles by BURBAUD, P. Anxiety Disorders (General) Depression Other Somatic Therapy

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