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Prolactin Elevation With Ziprasidone

To the Editor: With the exception of risperidone, atypical antipsychotics have been thought to elevate prolactin only transiently (1–3). We report on a 41-year-old woman who developed clinically significant hyperprolactinemia while taking both risperidone and ziprasidone, which resolved with the introduction of quetiapine.

Ms. A had a history of bipolar disorder and developed postpartum psychosis after her first child was born. She responded to lithium and risperidone. After the delivery of a second child while taking lithium, she again required risperidone (1.5 mg/day) for mood instability and obsessive ruminations about harming her baby. She had trace cogwheeling but no other extrapyramidal symptoms. She did not breast-feed, but she was amenorrheic for several months. Her prolactin level was 164.5 ng/ml. Brain magnetic resonance imaging showed no evidence of a pituitary microadenoma. Two weeks after she stopped taking risperidone, her prolactin level returned to normal, and she menstruated 1 week later. Because her ruminations returned, she was given oral ziprasidone, starting at 20 mg b.i.d., increased over 2 weeks to 60 mg b.i.d. for 3 weeks, then lowered to 100 mg at bedtime for 2 weeks because of sedation. Her ruminations disappeared, but she developed 1+ cogwheeling, tremor, and masked facies and did not menstruate; her prolactin level rose to 124 ng/ml.

Ms. A was switched to quetiapine (400 mg/day) with resolution of extrapyramidal symptoms and a decrease in her prolactin level to 8.2 ng/ml. Her menses resumed within 3 weeks of stopping ziprasidone and remained regular for at least a year. Her prolactin level remained normal.

To our knowledge, this is the second case documenting clinically significant hyperprolactinemia with ziprasidone (4). Our patient concurrently had extrapyramidal symptoms, implying dopamine D₂ receptor antagonism in the nigrostriatal and tuberoinfundibular tracts (1). Quetiapine did not produce either side effect, consistent with its relatively weak and transient binding at D₂ receptors compared to risperidone and ziprasidone and its tolerance in patients with Parkinson’s disease (1, 5).

Although a case report showed reversal of risperidone-induced hyperprolactinemia upon switching to ziprasidone, our findings illustrate the potential of ziprasidone at average doses to cause clinically significant hyperprolactinemia (6). Of note, the only symptom of hyperprolactinemia in men may be sexual dysfunction (1).

References

1. Maguire GA: Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry 2002; 63(suppl 4):56–62
2. Bench CJ, Lammertsma AA, Grasby PM, Dolan RJ, Warrington SJ, Boyce M, Gunn KP, Brannick LY, Frackowiak RS: The time course of binding to striatal dopamine D2 receptors by the neuroleptic ziprasidone (CP-88,059–01) determined by positron emission tomography. Psychopharmacology (Berl) 1996; 124:141–147[CrossRef][Medline]
3. Miceli JJ, Wilner KD, Hansen RA, Johnson AC, Apseloff G, Gerber N: Single and multiple-dose pharmacokinetics of ziprasidone under non-fasting conditions in healthy male volunteers. Br J Clin Pharmacol 2000; 49(suppl 1):5S-13S
4. Jordan MP: Ziprasidone-associated galactorrhea in a female teenager. J Am Acad Child Adolesc Psychiatry 2003; 42:4–5[CrossRef][Medline]
5. Friedman JH, Fernandez HH: Atypical antipsychotics in Parkinson-sensitive populations. J Geriatr Psychiatry Neurol 2002; 15:156–170
6. Kunwar AR, Megna JL, Gorman JM: Ziprasidone substitution in a patient with risperidone-induced hyperprolactinemia. J Psychiatr Pract 2003; 9:245–247[Medline]

Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via Google Scholar Articles by LUSSKIN, S. I. Articles by JACOBSON, J. Search for Related Content PubMed Citation Articles by LUSSKIN, S. I. Articles by JACOBSON, J. Neuroendocrinology Bipolar Disorder Atypical Neuroleptics

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