Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via Google Scholar Articles by LOVELL, R. W. Search for Related Content PubMed Citation Articles by LOVELL, R. W.

Mood Stabilizer Combinations for Bipolar Disorder

To the Editor: The article by Marlene P. Freeman, M.D., and Andrew L. Stoll, M.D., on combinations of mood stabilizers for treatment of bipolar disorder (1) noted the potentially dangerous interaction of lamotrigine with valproate. Unfortunately, the authors failed to mention that the risk of severe and at times fatal rashes associated with lamotrigine is much higher in the pediatric population. Readers should have been reminded of the one in 50 to one in 100 chance of life-threatening rashes associated with the use of lamotrigine in children and adolescents under 16 years. The product information monograph bears a boxed warning emphasizing that lamotrigine is not approved for use in patients below the age of 16 years.

REFERENCES

1. Freeman MP, Stoll AL: Mood stabilizer combinations: a review of safety and efficacy. Am J Psychiatry 1998; 155:12–21[Abstract/Free Full Text]

Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via Google Scholar Articles by LOVELL, R. W. Search for Related Content PubMed Citation Articles by LOVELL, R. W.

Get information about faster international access.

Privacy Policy

Copyright © 1999 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us