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Am J Psychiatry 98:668-672, March 1942
doi: 10.1176/appi.ajp.98.5.668
© 1942 American Psychiatric Association
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EXPERIMENTAL "SHOCK THERAPIES" IN CATS WITH INSULIN AND METRAZOL

Histopathologic Study

META A. NEUMANN M. S.1, ROBERT COHN M. D.1, , and SOLOMON KATZENELBOGEN M. D.1

1 Saint Elizabeths Hospital, Washington, D. C.

The effect of sniffles on the central nervous system is difficult to evaluate. We are also at a loss to explain the peculiar changes of the pulmonary vessels. We were unable to find any references in the literature pertaining to this condition. Congestion and hemorrhages in thoracic and abdominal organs were equally pronounced in both treated and control animals.

It should be emphasized that in every animal brain one could see instances of ischemic homogeneous changes as well as acute pallor, swelling and chromatolysis, often side by side. Cells undergoing cyto-or karyolysis could always be found. Other neurocytes were entirely normal and showed well-stained Nissl substance.

In view of the findings of other workers, Ammon's horn was studied with particular care in every instance. We agree with Winkleman's and Moore's observations that there are no widespread changes in this area subsequent to either insulin or metrazol injections.







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