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Am J Psychiatry 97:677-685, November 1940
doi: 10.1176/appi.ajp.97.3.677
© 1940 American Psychiatric Association
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NITROUS OXIDE ANOXIA IN THE TREATMENT OF SCHIZOPHRENIA

Report of 24 Cases.

E. J. FOGEL M. D.1, and L. P. GRAY M. D.1

1 Warren State Hospital, Warren, Pa.

1. Nitrous oxide anoxia has given good results in the treatment of early cases of schizophrenia.

2. Chronic cases, whose illness was over 2 years in duration were unchanged.

3. It is a relatively safe method in the hands of a skilled anæsthetist. The dangers of respiratory failure and irreversible damage to the brain must be remembered.

4. Nitrous oxide anoxia is less time consuming than hypoglycemia, and therefore is available to a larger group of patients.

5. The treatment is less strenuous on the patient and most of them enjoy the daily bout.

6. No accidents or untoward effects have been experienced in our series.

7. Whereas the number of cases treated so far is too small to have much statistical validity, we feel that our results are sufficiently good to warrant treating early cases by this method first. If they fail to improve after a fair trial, they can be transferred to insulin treatment.

8. This technique might be used in general hospitals in treating early cases of schizophrenia.







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