PHYSIOLOGICAL STUDIES OF EXPERIMENTAL INSULIN AND METRAZOL SHOCK
II. Vascular and Respiratory Responses During Metrazol Convulsions.
D. W. LOUGHEED 1, and
G. EDWARD HALL 1
1 Department of Medical Research, Banting Institute, University of Toronto.
Some of the physiological and biochemical changes characteristically associated with the various specific stages of the convulsions produced by the intravenous injection of metrazol have been studied in unanæsthetized rabbits.
The changes in the heart-rate, systemic and pulmonary blood pressure, splanchnic volume, respiration and blood gases are of sudden onset and of marked degree.
The severity of these changes is such that the possibility of a hazard being associated with the clinical use of metrazol must be borne in mind.
