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Am J Psychiatry 89:751-768, January 1933
doi: 10.1176/appi.ajp.89.4.751
© 1933 American Psychiatric Association
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CEREBRAL BIRTH CONDITIONS WITH SPECIAL REFERENCE TO THE FACTOR OF HEMORRHAGE

Clarence A. Patten M. D., and Bernard J. Alpers M. D.

It has been maintained in a previous work that many of the cerebral birth conditions are primarily due to failure of development of the brain, particularly in the realm of myelinization. Further evidence of this is brought out in a study of 30 infant brains, both premature and term. Here were found punctate and large hemorrhages in the subependymal region involving the matrix area, causing destruction of and interference with spongioblasts which would eventually be concerned in the deposit of myelin by virtue of their development into oliogodendroglia. The factor of subarachnoid hemorrhage as a cause of these cerebral conditions is discounted as compared with the more vital hemorrhage in the subependymal region. The cause of these hemorrhages is not clear







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