Am J Psychiatry 164:1050-1060, July 2007
doi: 10.1176/appi.ajp.164.7.1050
© 2007 American Psychiatric Association
Efficacy and Tolerability of Olanzapine, Quetiapine, and Risperidone in the Treatment of Early Psychosis: A Randomized, Double-Blind 52-Week Comparison
Joseph P. McEvoy, M.D.,
Jeffrey A. Lieberman, M.D.,
Diana O. Perkins, M.D., M.P.H.,
Robert M. Hamer, Ph.D.,
Hongbin Gu, Ph.D.,
Arthur Lazarus, M.D., M.B.A.,
Dennis Sweitzer, Ph.D.,
Christina Olexy,
Peter Weiden, M.D., and
Stephen D. Strakowski, M.D.
OBJECTIVE: This 52-week randomized, double-blind, flexible-dose, multicenter study evaluated the overall effectiveness (as measured by treatment discontinuation rates) of olanzapine, quetiapine, and risperidone in patients early in the course of psychotic illness. METHOD: Patients were randomly assigned to treatment with olanzapine (2.5–20 mg/day), quetiapine (100–800 mg/day), or risperidone (0.5–4 mg/day) administered in twice-daily doses. Statistical analyses tested for noninferiority in all-cause treatment discontinuation rates up to 52 weeks (primary outcome measure) based on a prespecified noninferiority margin of 20%. RESULTS: A total of 400 patients were randomly assigned to treatment with olanzapine (N=133), quetiapine (N=134), or risperidone (N=133). The mean modal prescribed daily doses were 11.7 mg for olanzapine, 506 mg for quetiapine, and 2.4 mg for risperidone. At week 52, all-cause treatment discontinuation rates were 68.4%, 70.9%, and 71.4% for olanzapine, quetiapine, and risperidone, respectively. Reductions in total score on the Positive and Negative Syndrome Scale (PANSS) were similar for the three treatment groups, but reductions in PANSS positive subscale scores were greater in the olanzapine group (at 12 weeks and at 52 weeks or withdrawal from study) and the risperidone group (at 12 weeks). The most common elicited adverse events for olanzapine were drowsiness (53%), weight gain (51%), and insomnia (38%); for quetiapine, drowsiness (58%), increased sleep hours (42%), and weight gain (40%); and for risperidone, drowsiness (50%), menstrual irregularities in women (47%), and weight gain (41%). CONCLUSIONS: Olanzapine, quetiapine, and risperidone demonstrated comparable effectiveness in early-psychosis patients, as indicated by similar rates of all-cause treatment discontinuation.
Related Article:
-
In This Issue
Am J Psychiatry 2007 164: A46.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
M. Alvarez-Jimenez, A. G. Parker, S. E. Hetrick, P. D. McGorry, and J. F. Gleeson
Preventing the Second Episode: A Systematic Review and Meta-analysis of Psychosocial and Pharmacological Trials in First-Episode psychosis
Schizophr Bull,
November 9, 2009;
(2009)
sbp129v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. U. Correll, P. Manu, V. Olshanskiy, B. Napolitano, J. M. Kane, and A. K. Malhotra
Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
JAMA,
October 28, 2009;
302(16):
1765 - 1773.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Bibliography Schizophrenia
Focus,
April 1, 2008;
6(2):
197 - 199.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Kane and S. Leucht
Unanswered Questions in Schizophrenia Clinical Trials
Schizophr Bull,
March 1, 2008;
34(2):
302 - 309.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Leucht, S. Heres, J. Hamann, and J. M. Kane
Methodological Issues in Current Antipsychotic Drug Trials
Schizophr Bull,
March 1, 2008;
34(2):
275 - 285.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 2007
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
