Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Hall, M.-H. Articles by Sham, P. Search for Related Content PubMed Citation Articles by Hall, M.-H. Articles by Sham, P. Neurophysiology Schizophrenia Spectrum Disorders Genetics Related Article

Substantial Shared Genetic Influences on Schizophrenia and Event-Related Potentials

OBJECTIVE: Several components of event-related potentials—P50 suppression, P300 amplitude and latency, and mismatch negativity—have been proposed as potential endophenotypes for schizophrenia on the basis of family studies. The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia. METHOD: The authors measured mismatch negativity, P300, and P50 suppression in 16 monozygotic twin pairs concordant for schizophrenia, nine monozygotic twin pairs discordant for schizophrenia, and 78 healthy comparison twin pairs. The study design was based on a power calculation. Structural equation modeling was used to quantify the genetic and environmental contributions to the phenotypic covariance between schizophrenia and each of the event-related potential indices. RESULTS: Significant phenotypic correlation with schizophrenia was found for each of the event-related potential components. Genetic factors were the main source of the phenotypic correlations. P50 suppression had the greatest genetic correlation with schizophrenia, followed by P300 amplitude, P300 latency, and mismatch negativity. CONCLUSIONS: All four event-related potential indices are potentially valid endophenotypes for schizophrenia, but P50 suppression and P300 amplitude show the closest genetic relationship to schizophrenia.

Related Article:

In This Issue
Am J Psychiatry 2007 164: A56. [Full Text] [PDF]

This article has been cited by other articles:

				T. Toulopoulou, M. Picchioni, F. Rijsdijk, M. Hua-Hall, U. Ettinger, P. Sham, and R. Murray Substantial Genetic Overlap Between Neurocognition and Schizophrenia: Genetic Modeling in Twin Samples Arch Gen Psychiatry, December 1, 2007; 64(12): 1348 - 1355. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2007 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us