Confirmation That a Specific Haplotype of the Dopamine Transporter Gene Is Associated With Combined-Type ADHD

doi:10.1176/appi.ajp.164.4.674

Am J Psychiatry 164:674-677, April 2007
doi: 10.1176/appi.ajp.164.4.674
© 2007 American Psychiatric Association



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	Attention Deficit Hyperactivity Disorder
	Genetics

Brief Report

Confirmation That a Specific Haplotype of the Dopamine Transporter Gene Is Associated With Combined-Type ADHD

Philip Asherson, M.R.C.Psych., Ph.D., Keeley Brookes, B.Sc., Barbara Franke, Ph.D., Wai Chen, M.R.C.Psych., Michael Gill, M.R.C.Psych., Ph.D., Richard P. Ebstein, Ph.D., Jan Buitelaar, M.D., Ph.D., Tobias Banaschewski, M.D., Ph.D., Edmund Sonuga-Barke, Ph.D., Jacques Eisenberg, M.D., Iris Manor, M.D., Ana Miranda, M.D., Robert D. Oades, Ph.D., Herbert Roeyers, M.D., Ph.D., Aribert Rothenberger, M.D., Ph.D., Joseph Sergeant, Ph.D., Hans-Christoph Steinhausen, M.D., Ph.D., and Stephen V. Faraone, M.D., Ph.D.

OBJECTIVE: The primary purpose of this study was to confirmthe association of a specific haplotype of the dopamine transportergene and attention deficit hyperactivity disorder (ADHD), whichcould be one source of the heterogeneity seen across publishedstudies. METHOD: The authors previously reported the associationof ADHD with a subgroup of chromosomes containing specific allelesof two variable-number tandem repeat polymorphisms within the3' untranslated region and intron 8 of the dopamine transportergene. They now report on this association in a sample of ADHDcombined-type probands. RESULTS: The original observations wereconfirmed, with an overall odds ratio of 1.4 across samples.CONCLUSIONS: These data challenge results of meta-analyses suggestingthat dopamine transporter variation does not have an effecton the risk for ADHD, and they indicate that further investigationof functional variation in the gene is required.

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