Full Text Full Text (PDF) Data Supplement Correction (v164,p1123) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Garrity, A. G. Articles by Calhoun, V. D. Search for Related Content PubMed Citation Articles by Garrity, A. G. Articles by Calhoun, V. D. Other Neuroanatomy fMR Schizophrenia Spectrum Disorders Related Article

Aberrant "Default Mode" Functional Connectivity in Schizophrenia

OBJECTIVE: The "default mode" has been defined as a baseline condition of brain function and is of interest because its component brain regions are believed to be abnormal in schizophrenia. It was hypothesized that the default mode network would show abnormal activation and connectivity in patients with schizophrenia. METHOD: Patients with schizophrenia (N=21) and healthy comparison subjects (N=22) performed an auditory oddball task during functional magnetic resonance imaging (fMRI). Independent component analysis was used to identify the default mode component. Differences in the spatial and temporal aspects of the default mode network were examined in patients versus comparison subjects. RESULTS: Healthy comparison subjects and patients had significant spatial differences in the default mode network, most notably in the frontal, anterior cingulate, and parahippocampal gyri. In addition, activity in patients in the medial frontal, temporal, and cingulate gyri correlated with severity of positive symptoms. The patients also showed significantly higher frequency fluctuations in the temporal evolution of the default mode. CONCLUSIONS: Schizophrenia is associated with altered temporal frequency and spatial location of the default mode network. The authors hypothesized that this network may be under- or overmodulated by key regions, including the anterior and posterior cingulate cortex. In addition, the altered temporal fluctuations in patients may result from a change in the connectivity of these regions with other brain networks.

Related Article:

In This Issue
Am J Psychiatry 2007 164: 62. [Full Text] [PDF]

This article has been cited by other articles:

				Y. Liu, M. Liang, Y. Zhou, Y. He, Y. Hao, M. Song, C. Yu, H. Liu, Z. Liu, and T. Jiang Disrupted small-world networks in schizophrenia Brain, April 1, 2008; 131(4): 945 - 961. [Abstract] [Full Text] [PDF]

				R. L. BUCKNER, J. R. ANDREWS-HANNA, and D. L. SCHACTER The Brain's Default Network: Anatomy, Function, and Relevance to Disease Ann. N.Y. Acad. Sci., March 1, 2008; 1124(1): 1 - 38. [Abstract] [Full Text] [PDF]

				J. S. Damoiseaux, C. F. Beckmann, E. J. S. Arigita, F. Barkhof, Ph. Scheltens, C. J. Stam, S. M. Smith, and S. A. R. B. Rombouts Reduced resting-state brain activity in the "default network" in normal aging Cereb Cortex, December 27, 2007; (2007) bhm207v2. [Abstract] [Full Text] [PDF]

				C. Sorg, V. Riedl, M. Muhlau, V. D. Calhoun, T. Eichele, L. Laer, A. Drzezga, H. Forstl, A. Kurz, C. Zimmer, et al. Selective changes of resting-state networks in individuals at risk for Alzheimer's disease PNAS, November 20, 2007; 104(47): 18760 - 18765. [Abstract] [Full Text] [PDF]

				K. O. Lim Connections in Schizophrenia Am J Psychiatry, July 1, 2007; 164(7): 995 - 998. [Full Text] [PDF]

				P. Williamson Are Anticorrelated Networks in the Brain Relevant to Schizophrenia? Schizophr Bull, July 1, 2007; 33(4): 994 - 1003. [Abstract] [Full Text] [PDF]

				P. Williamson The Final Common Pathway of Schizophrenia Schizophr Bull, July 1, 2007; 33(4): 953 - 954. [Full Text] [PDF]

				R. L. Bluhm, J. Miller, R. A. Lanius, E. A. Osuch, K. Boksman, R. Neufeld, J. Theberge, B. Schaefer, and P. Williamson Spontaneous Low-Frequency Fluctuations in the BOLD Signal in Schizophrenic Patients: Anomalies in the Default Network Schizophr Bull, July 1, 2007; 33(4): 1004 - 1012. [Abstract] [Full Text] [PDF]

				Emerging Perspectives: Peering into the Brain's "Black Box" in Schizophrenia Journal Watch Psychiatry, April 13, 2007; 2007(413): 1 - 1. [Full Text]

Get information about faster international access.

Privacy Policy

Copyright © 2007 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us