Am J Psychiatry 164:248-258, February 2007
doi: 10.1176/appi.ajp.164.2.248
© 2007 American Psychiatric Association
Genetics of Recurrent Early-Onset Major Depression (GenRED): Final Genome Scan Report
Peter Holmans, Ph.D.,
Myrna M. Weissman, Ph.D.,
George S. Zubenko, M.D., Ph.D.,
William A. Scheftner, M.D.,
Raymond R. Crowe, M.D.,
J. Raymond DePaulo Jr., , M.D.,
James A. Knowles, M.D., Ph.D.,
Wendy N. Zubenko, Ed.D.,
Kathleen Murphy-Eberenz, Ph.D.,
Diana H. Marta, M.S.N.,
Sandra Boutelle, M.S.,
Melvin G. McInnis, M.D.,
Philip Adams, Ph.D.,
Madeline Gladis, Ph.D.,
Jo Steele, B.A.,
Erin B. Miller, M.S.,
James B. Potash, M.D., M.P.H.,
Dean F. MacKinnon, M.D., and
Douglas F. Levinson, M.D.
OBJECTIVE: The authors carried out a genomewide linkage scan to identify chromosomal regions likely to contain genes that contribute to susceptibility to recurrent early-onset major depressive disorder, the form of the disorder with the greatest reported risk to relatives of index cases. METHOD: Microsatellite DNA markers were studied in 656 families with two or more such cases (onset before age 31 in probands and age 41 in other relatives), including 1,494 informative "all possible" affected relative pairs (there were 894 independent affected sibling pairs). Analyses included a primary multipoint allele-sharing analysis (with ALLEGRO) and a secondary logistic regression analysis taking the sex of each relative pair into account (male-male, male-female, female-female). RESULTS: Genomewide suggestive evidence for linkage was observed on chromosome 15q25-q26 (at 105.4 centimorgans [cM]). The authors previously reported genomewide significant linkage in this region in the first 297 families. In the secondary analysis, after empirical genomewide correction for multiple testing, suggestive linkage results were observed on chromosome 17p12 (28.0 cM, excess sharing in male-male and male-female pairs) and on chromosome 8p22-p21.3 (25.1 cM, excess sharing in male-male pairs). CONCLUSIONS: These regions of chromosomes 15q, 17p, and 8p might contain genes that contribute to susceptibility to major depression and related disorders. Evidence for linkage has been reported independently in the same regions of chromosome 15q for major depression and of chromosome 8p for related personality traits.
Related Article:
-
In This Issue
Am J Psychiatry 2007 164: 50.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
Y. Feng, A. Vetro, E. Kiss, K. Kapornai, G. Daroczi, L. Mayer, Z. Tamas, I. Baji, J. Gadoros, N. King, et al.
Association of the Neurotrophic Tyrosine Kinase Receptor 3 (NTRK3) Gene and Childhood-Onset Mood Disorders
Am J Psychiatry,
May 1, 2008;
165(5):
610 - 616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.H. Belmaker and G. Agam
Major Depressive Disorder
N. Engl. J. Med.,
January 3, 2008;
358(1):
55 - 68.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Grover, A. S. Woodfield, R. Verma, P. P. Zandi, D. F. Levinson, and J. B. Potash
QuickSNP: an automated web server for selection of tagSNPs
Nucleic Acids Res.,
July 13, 2007;
35(suppl_2):
W115 - W120.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 2007
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
