Full Text Full Text (PDF) Title Correction: Social Cognition and Neurocognition Correction (v164,p1766) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Sergi, M. J. Articles by Mintz, J. Search for Related Content PubMed Citation Articles by Sergi, M. J. Articles by Mintz, J. Atypical Neuroleptics Conventional Neuroleptics Schizophrenia Spectrum Disorders Cognition

Social Cognition and Neurocognition: Effects of Risperidone, Olanzapine, and Haloperidol

OBJECTIVE: This study examined the short-term effects of first- and second-generation antipsychotic medications on social cognition and basic cognition. METHOD: One hundred patients with schizophrenia or schizoaffective disorder participated in an 8 week, double-blind study of risperidone, olanzapine, and haloperidol. Participants were administered multiple measures of social cognition, basic cognition, and clinical symptoms at baseline, the end of week 4, and the end of week 8. Seventy-three patients completed the baseline assessment and at least one other assessment. Data were analyzed with mixed-effects analyses of covariance. For data reduction, the social cognitive measures were clustered into a summary score, and the cognitive measures were clustered into two summary scores: general cognitive ability and processing speed. (The effects on thinking of risperidone and olanzapine can be found at NCT00108368, www.clinicaltrials.gov.) RESULTS: There were no treatment-related differences on any of the three summary scores. Social cognition did not show within-group changes over time either by itself or after control for the cognitive clusters. One cognitive score (general cognitive ability) increased during the study period for all three medication groups. CONCLUSIONS: The present study included a rather thorough assessment of social cognition and did not find any evidence of between-group or within-group effects of antipsychotic medication on social cognition.

This article has been cited by other articles:

				S. M. Eack, D. P. Greenwald, S. S. Hogarty, S. J. Cooley, A. L. DiBarry, D. M. Montrose, and M. S. Keshavan Cognitive Enhancement Therapy for Early-Course Schizophrenia: Effects of a Two-Year Randomized Controlled Trial Psychiatr Serv, November 1, 2009; 60(11): 1468 - 1476. [Abstract] [Full Text] [PDF]

				S. G. Potkin, J. A. Turner, G. G. Brown, G. McCarthy, D. N. Greve, G. H. Glover, D. S. Manoach, A. Belger, M. Diaz, C. G. Wible, et al. Working memory and DLPFC inefficiency in schizophrenia: The FBIRN study Schizophr Bull, January 1, 2009; 35(1): 19 - 31. [Abstract] [Full Text] [PDF]

				C. S. Carter, D. M. Barch, R. Gur, R. Gur, A. Pinkham, and K. Ochsner CNTRICS Final Task Selection: Social Cognitive and Affective Neuroscience-Based Measures Schizophr Bull, January 1, 2009; 35(1): 153 - 162. [Abstract] [Full Text] [PDF]

				M. F. Green, D. L. Penn, R. Bentall, W. T. Carpenter, W. Gaebel, R. C. Gur, A. M. Kring, S. Park, S. M. Silverstein, and R. Heinssen Social Cognition in Schizophrenia: An NIMH Workshop on Definitions, Assessment, and Research Opportunities Schizophr Bull, November 1, 2008; 34(6): 1211 - 1220. [Abstract] [Full Text] [PDF]

				2007 in Review Am J Psychiatry, December 1, 2007; 164(12): 1780 - 1783. [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2007 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us