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Effects of Parental PTSD on the Cortisol Response to Dexamethasone Administration in Their Adult Offspring

OBJECTIVE: The authors used a low-dose dexamethasone suppression test to examine the effect of a PTSD risk factor, parental PTSD, on cortisol negative feedback inhibition in adult offspring of Holocaust survivors with PTSD (N=13) versus without PTSD (N=12) as well as a comparison group of offspring whose parents had no Holocaust exposure (N=16). METHOD: Blood samples were obtained at 8:00 a.m. for the determination of baseline cortisol. Participants ingested 0.5 mg of dexamethasone at 11:00 p.m., and blood samples were obtained again at 8:00 a.m. the following day. RESULTS: Enhanced cortisol suppression in response to dexamethasone was associated primarily with parental PTSD status, with minimal contribution of subjects’ own trauma-related symptoms. CONCLUSIONS: Enhanced cortisol negative feedback inhibition may be associated with PTSD because it is related to the PTSD risk factor of parental PTSD.

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				J. B. Becker, L. M. Monteggia, T. S. Perrot-Sinal, R. D. Romeo, J. R. Taylor, R. Yehuda, and T. L. Bale Stress and Disease: Is Being Female a Predisposing Factor? J. Neurosci., October 31, 2007; 27(44): 11851 - 11855. [Full Text] [PDF]

				R. Yehuda, M. H. Teicher, J. R. Seckl, R. A. Grossman, A. Morris, and L. M. Bierer Parental Posttraumatic Stress Disorder as a Vulnerability Factor for Low Cortisol Trait in Offspring of Holocaust Survivors Arch Gen Psychiatry, September 1, 2007; 64(9): 1040 - 1048. [Abstract] [Full Text] [PDF]

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