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No Improvement of Posttraumatic Stress Disorder Symptoms With Guanfacine Treatment

OBJECTIVE: The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD). METHOD: Veterans with chronic PTSD who were medication-free or receiving stable pharmacotherapy were randomly assigned to guanfacine (N=29) versus placebo (N=34). RESULTS: Guanfacine had no effect on PTSD symptoms, subjective sleep quality, or general mood disturbances. Guanfacine was associated with a number of side effects. CONCLUSIONS: These results do not support the use of alpha 2 agonists in veterans with chronic PTSD.

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				R. B. Lydiard and M. H. Hamner Clinical Importance of Sleep Disturbance as a Treatment Target in PTSD Focus, April 1, 2009; 7(2): 176 - 183. [Abstract] [Full Text] [PDF]

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