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Am J Psychiatry 163:2000-2002, November 2006
doi: 10.1176/appi.ajp.163.11.2000
© 2006 American Psychiatric Association
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Brief Report

Validation of Remission Criteria for Schizophrenia

Jim van Os, M.D., Ph.D., Marjan Drukker, Ph.D., Joost à Campo, M.D., Ph.D., Jaap Meijer, M.D., M. Bak, M.D., Ph.D., and Philippe Delespaul, Ph.D.

OBJECTIVE: Remission criteria for schizophrenia have been proposed, consisting of a time criterion and a symptomatic remission criterion. With longitudinal data of a representative patient group (N=317; median follow-up: 1,132 days), validity of the symptomatic remission criterion was investigated. METHOD: In a group of 145 patients meeting the symptomatic remission criterion at baseline and a group of 172 patients not meeting it at baseline, change over time in remission status was examined in relation to change in various functional outcomes. RESULTS: In both groups, change over time with the symptomatic remission criterion was associated with substantial changes in unmet needs, Global Assessment of Functioning scale scores, satisfaction with services and, to a lesser extent, quality of life. Changing the symptomatic remission criterion to include depression and suicidality did not affect the results. CONCLUSIONS: The proposed symptomatic remission criterion has clinical validity and represents the right balance between parsimony and inclusiveness.




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